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- Table of Contents
MKI67 Antibodies
AND MKI67 ELISA kits, MKI67 Proteins
Many biological assays use antibodies to detect MKI67, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MKI67 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MKI67 antibodies...
Designing a Western blot for MKI67? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MKI67 Western Blot GuideMKI67 Infographic by Boster Bio
All MKI67 Products
Product
Figures
Specificity
Applications
Price
Anti-Ki67 Antibody Picoband® (monoclonal, 5C7)
18 Citations
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00254-9
100 μg/vial
Cat # M00254-9
100 μg/vial
Anti-Ki67 Antibody (monoclonal, 5E12)
7 Citations
Human
Flow Cytometry, IF, IHC, ICC
$370
Cat # M00254-8
100 μg/vial
Cat # M00254-8
100 μg/vial
Anti-Ki67 MKI67 Rabbit Monoclonal Antibody
3 Citations
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00254
100 μl
Cat # M00254
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00254-10
20μL, 40μL, 100μL, 200μL
Cat # M00254-10
20μL, 40μL, 100μL, 200μL
MKI67 Overview
Facts about Proliferation marker protein Ki-67.
Proliferation marker protein Ki-67 (MKI67)
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a significant portion of the chromosome surface (PubMed:27362226).
Prevents chromosomes from collapsing to a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551).
Gene Information
| Human | |
|---|---|
| Gene Name: | MKI67 |
| Uniprot: | P46013 |
| Entrez: | 4288 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
antigen identified by monoclonal Ki-67; Antigen Ki67; antigen KI-67; antiKi67; Ki67 ihc; Ki-67 ihc; Ki67 mouse; Ki-67 mouse; Ki67 western blot; Ki-67 western blot; Ki67; Ki-67; KIA; Marker Of Proliferation Ki-67; MIB-; MIB-1; MKI67; PPP1R105; Proliferation Marker Protein Ki-67; proliferation-related Ki-67 antigen; Protein Phosphatase 1; Regulatory Subunit 105; TSG126
Molecular Weight
Mass (kDA):
358.694 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.2 |
| Sequence: | 10; NC_000010.11 (128096659..128126423, complement) |
Subcellular Localizations
Chromosome. Nucleus. Nucleus, nucleolus. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being
Diseases
- Neoplasms
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Hyperplasia
- Prostatic Neoplasms
- Tumor Angiogenesis
- Malignant Neoplasm Of Prostate
- Endometrial Polyp
- Tissue Adhesions
- Adenocarcinoma
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- KIF15
- NIFK
Pathways
- Cell Proliferation
- Cell Cycle
- Neurogenesis
- Pathogenesis
- Angiogenesis
- Mitosis
- Cell Growth
- Cell Division
- Epithelial Cell Proliferation
- Localization
- Regeneration
- Dedifferentiation
- Senescence
PTMs
- Phosphorylation
- Methylation
Research Areas
- Breast Cancer
- Cancer
- Cell Biology
- Cell Cycle and Replication
- Cellular Markers
- Chromatin Research
- Mitotic Regulators
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MKI67
bosterbio.com/bosterbio-gene-info-cards/MKI67
References
PMID: 8227122 by Schlueter C., et al. The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.
PMID: 6339421 by Gerdes J., et al. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation.
95 Publications of Boster MKI67 Antibodies & ELISA Kits
- PubMed ID: PMID:31966612, Clinical biocharacterization of immunophenotype in hepatocellular carcinoma pati...
- PubMed ID: PMID:30210698, Identification and differentiation therapy strategy of pterygium in vitro
- PubMed ID: 10.3892/ol.2021.12762, Antimicrobial peptide 17BIPHE2 inhibits the proliferation of lung cancer cells <...
- PubMed ID: 10.3892/ol.2016.4690, Label-retaining assay enriches tumor-initiating cells in glioblastoma spheres cu...
- PubMed ID: 10.3892/ol.2016.4380, Preclinical pharmacodynamic evaluation of antibiotic nitroxoline for anticancer ...
- PubMed ID: 10.3892/ijmm.2021.5071, Microrchidia family CW‑type zinc finger 2 promotes the proliferation, invasio...
- PubMed ID: 10.3748/wjg.v13.i48.6558, PlexinA1 expression in gastric carcinoma and its relationship with tumor angioge...
- PubMed ID: 10.2485/jhtb.30.273, Elevated CREPT Expression Enhances the Progression of Salivary Gland Adenoid Cys...
- PubMed ID: 10.1186/s13046-021-02120-4, Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune chec...
- PubMed ID: 10.1186/s12935-021-01775-5, Regulator of cullins-1 (ROC1) negatively regulates the Gli2 regulator SUFU to ac...
- PubMed ID: 10.1186/s12935-020-1150-1, Hsa_circ_0137008 suppresses the malignant phenotype in colorectal cancer by acti...
- PubMed ID: 10.1186/1471-2407-9-315, Cripto-1 overexpression is involved in the tumorigenesis of nasopharyngeal carci...
- PubMed ID: 10.1161/ATVBAHA.120.315525, Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Ce...
- PubMed ID: 10.1158/1541-7786.MCR-12-0632, Balanced Tiam1-Rac1 and RhoA Drives Proliferation and Invasion of Pancreatic Can...
- PubMed ID: 10.1111/j.1440-1797.2008.00939.x, R2: Identification of renal potential progenitor/stem cells that participate in ...
- PubMed ID: 10.1111/apm.12427, Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosa...
- PubMed ID: 10.1093/carcin/bgr035, Low-level expression of let-7a in gastric cancer and its involvement in tumorige...
- PubMed ID: 10.1088/1758-5090/8/4/045005, 3D bioprinted glioma stem cells for brain tumor model and applications of drug s...
- PubMed ID: 10.1080/13880209.2021.1944224, Cryptotanshinone enhances the efficacy of Bcr-Abl tyrosine kinase inhibitors via...
- PubMed ID: 10.1038/srep27559, Core-shell nanocarriers with high paclitaxel loading for passive and active targ...
- PubMed ID: 10.1038/s41419-020-03064-x, PRMT5/Wnt4 axis promotes lymph-node metastasis and proliferation of laryngeal ca...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page