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- Table of Contents
PECAM1 Antibodies
AND PECAM1 ELISA kits, PECAM1 Proteins
Many biological assays use antibodies to detect PECAM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PECAM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PECAM1 antibodies...
Designing a Western blot for PECAM1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PECAM1 Western Blot GuidePECAM1 Infographic by Boster Bio
All PECAM1 Products
Product
Figures
Specificity
Applications
Price
Anti-CD31/Pecam1 Antibody Picoband®
84 Citations
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A01513-3
100 μg/vial
Cat # A01513-3
100 μg/vial
Anti-CD31/PECAM1 Antibody Picoband®
4 Citations
Human
Flow Cytometry, IHC, WB
$370
Cat # PB9094
100 μg/vial
Cat # PB9094
100 μg/vial
Anti-CD31/Pecam1 Antibody Picoband®
3 Citations
Mouse, Rat
ELISA, IHC, WB
$370
Cat # A01513-2
100 μg/vial
Cat # A01513-2
100 μg/vial
Human
IHC, IHC-F, WB
$370
Cat # M01513-4
100 μg/vial
Cat # M01513-4
100 μg/vial
Human
ELISA
$499
Cat # FEK0873
96 wells/kit, with removable strips.
Cat # FEK0873
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # EK0873
96 wells/kit, with removable strips.
Cat # EK0873
96 wells/kit, with removable strips.
Human, Mouse, Rat
IHC, WB
$370
Cat # M01528-2
100 μg/vial
Cat # M01528-2
100 μg/vial
Anti-CD31 PECAM1 Rabbit Monoclonal Antibody
3 Citations
Human
Flow Cytometry, IP, IHC, WB
$370
Cat # M01513-1
100 μl
Cat # M01513-1
100 μl
Mouse
ELISA
$499
Cat # FEK0874
96 wells/kit, with removable strips.
Cat # FEK0874
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK0874
96 wells/kit, with removable strips.
Cat # EK0874
96 wells/kit, with removable strips.
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M01537-1
100 μg/vial
Cat # M01537-1
100 μg/vial
Human
Flow Cytometry, IHC, WB
$370
Cat # M01513-2
100 μl
Cat # M01513-2
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01513-7
20μL, 40μL, 100μL, 200μL
Cat # M01513-7
20μL, 40μL, 100μL, 200μL
Human
ELISA, IP, IF, IHC, WB
$146
Cat # M01513-6
20μL, 40μL, 100μL, 200μL
Cat # M01513-6
20μL, 40μL, 100μL, 200μL
Human, Mouse
ELISA
$540
Cat # EKC2561
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2561
1 kit, containing two 96-well plates and all necessary reagents
PECAM1 Overview
Facts about Platelet endothelial cell adhesion molecule.
Platelet endothelial cell adhesion molecule (PECAM1)
Cell adhesion molecule which is necessary for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is necessary for efficient trafficking of PECAM1 to and from the lateral boundary recycling compartment (LBRC) and is also critical for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684).
Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring possible leukocytes by transmitting a detachment signal (PubMed:12110892).
Gene Information
| Human | |
|---|---|
| Gene Name: | PECAM1 |
| Uniprot: | P16284 |
| Entrez: | 5175 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
adhesion molecule; CD31 antigen; CD31; CD31/EndoCAM; EndoCAM; FLJ34100; FLJ58394; GPIIA'; PECA1; PECAM1; PECAM-1; PECAM-1, CD31/EndoCAM; platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule
Molecular Weight
Mass (kDA):
82.522 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q23.3 |
| Sequence: | 17; NC_000017.11 (64319415..64413844, complement) |
Tissue Specificity
Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308). Expressed on neutrophils (at protein level) (PubMed:17580308). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation.; [Isoform Long]: Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell junction. Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.; [Isoform Delta15]: Cell junction. Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Diseases
- Tissue Adhesions
- Tumor Angiogenesis
- Pathologic Neovascularization
- Neoplasms
- Inflammation
- Malignant Neoplasms
- Von Willebrand Disease
- Infarction
- Myocardial Infarction
- Atherosclerosis
- Malaria
- Thrombosis
- Sclerosis
Interacting Proteins
- CTNNB1
- JUP
- PTPN11
- PTPN6
- SRC
Pathways
- Cell Adhesion
- Angiogenesis
- Localization
- Vasculogenesis
- Pathogenesis
- Cell Migration
- Cell Division
- Cell Differentiation
- Cell-cell Adhesion
- Cell Death
- Dedifferentiation
- Secretion
- Transport
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PECAM1
bosterbio.com/bosterbio-gene-info-cards/PECAM1
References
PMID: 2351935 by Simmons D.L., et al. Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen.
PMID: 1700999 by Stockinger H., et al. Molecular characterization and functional analysis of the leukocyte surface protein CD31.
77 Publications of Boster PECAM1 Antibodies & ELISA Kits
- PubMed ID: PMID:28386371, Immunomodulatory activity of interleukin-27 in human chronic periapical diseases
- PubMed ID: 10.4161/cbt.8.5.7687, Combined endostatin and TRAIL gene transfer suppresses human hepatocellular carc...
- PubMed ID: 10.4161/cbt.4.8.1891, Enhanced therapeutic effect by combination of tumor-targeting salmonella and end...
- PubMed ID: 10.3892/or_00000905, The pigment epithelial-derived factor gene loaded in PLGA nanoparticles for ther...
- PubMed ID: 10.3892/ol.2016.4690, Label-retaining assay enriches tumor-initiating cells in glioblastoma spheres cu...
- PubMed ID: 10.3760/cma.j.issn.0366-6999.2009.05.011, Solitary pulmonary nodules: comparison of multi-slice computed tomography perfus...
- PubMed ID: 10.3727/096368911X566181, Bone Marrow Mesenchymal Stem Cells in a Three-Dimensional Gelatin Sponge Scaffol...
- PubMed ID: 10.1254/jphs.14077FP, SKLB-M8 Induces Apoptosis Through the AKT/mTOR Signaling Pathway in Melanoma Mod...
- PubMed ID: 10.1167/iovs.61.11.40, Effect of Electrical Stimulation of Cervical Sympathetic Ganglia on Intraocular ...
- PubMed ID: 10.1155/2021/8279369, Aerobic Exercise Attenuates Pressure Overload-Induced Cardiac Dysfunction throug...
- PubMed ID: 10.1155/2020/9485398, Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1α/VEGF Signaling-R...
- PubMed ID: 10.1111/j.1745-7270.2007.00310.x, Soluble Fms‐like Tyrosine Kinase‐1 Expression Inhibits the Growth of Multipl...
- PubMed ID: 10.1097/SHK.0000000000000302, Angiotensin-Converting Enzyme Inhibition Attenuates Lipopolysaccharide-Induced L...
- PubMed ID: 10.1095/biolreprod.116.140939, EPHB4 Regulates Human Trophoblast Cell Line HTR-8/SVneo Function: Implications f...
- PubMed ID: 10.1039/D0NR08853F, Icebreaker-inspired Janus nanomotors to combat barriers in the delivery of chemo...
- PubMed ID: 10.1038/cddis.2014.544, Macrophage peroxisome proliferator-activated receptor γ deficiency delays skin ...
- PubMed ID: 10.1021/bc800132p, An RGD-Modified Endostatin-Derived Synthetic Peptide Shows Antitumor Activity in...
- PubMed ID: 10.1016/j.msec.2021.112171, Antibacterial polyvinyl alcohol/bacterial cellulose/nano-silver hydrogels that e...
- PubMed ID: 10.1016/j.msec.2016.06.036, Peptide-modified PELCL electrospun membranes for regulation of vascular endothel...
- PubMed ID: 10.1016/j.lfs.2010.03.013, Transplantation of endothelial progenitor cells alleviates renal interstitial fi...
- PubMed ID: 10.1016/j.cyto.2013.12.019, Expression of IL-17A and IL-17F in lipopolysaccharide-induced acute lung injury ...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page