- Table of Content
Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding action in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
|Sequence:||9; NC_000009.12 (110243810..110256507, complement)|
Nucleus. Cytoplasm. Secreted. Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947).
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