Many biological assays use antibodies to detect Complement C2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Complement C2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Complement C2 antibodies...
We validate the specificity of these antibodies to Complement C2 by testing them on tissues known to express C2 positively and negatively. Browse below to find the C2 antibody that suites your experiment. We have 74 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
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Gene Information
Human
Gene Name:
C2
Uniprot:
P06681
Entrez:
717
Family
Belongs to:
peptidase S1 family
Alternative Names
Complement Component C2b
Molecular Weight
Mass (kDA): 83.268 kDA
Genomic Context
Human
Location:
6p21.33
Sequence:
6; NC_000006.12 (31897783..31945674)
Subcellular Localizations
Secreted.
Diseases
Neoplasms
Fracture
Pain
Malignant Neoplasms
Carcinoma
Dislocations
Infective Disorder
Spinal Fractures
Spinal Cord Injuries
Neck Pain
Hiv Infections
Disease Of Adrenal Medulla
Hemorrhage
Immunologic Deficiency Syndromes
Lupus Erythematosus, Systemic
Flexed Fetal Attitude
Hemolysis (disorder)
Headache
Fracture Of First Cervical Vertebra
Inflammation
Pathways
Transport
Localization
Pathogenesis
Secretion
Complement Activation
Coagulation
Translation
Reflex
Cell Death
Proteolysis
Cell Cycle
Immune Response
Cell Proliferation
Fermentation
Glycosylation
Innervation
Cell Growth
Ossification
Methylation
Virulence
PTMs
Cleavage
Phosphorylation
Oxidation
Ribosylation
Glycosylation
Methylation
Reduction
Carboxylation
Hydroxylation
Nitration
Acetylation
Decarboxylation
Ubiquitination
Dephosphorylation
Biotinylation
Acylation
Amination
Deamination
Deglycosylation
Bromination
For details, visit: bosterbio.com/bosterbio-gene-info-cards/C2
References
PMID: 2949737 by Bentley D.R.; Primary structure of human complement component C2. Homology to two unrelated protein families.
PMID: 2493504 by Horiuchi T., et al. cDNA cloning and expression of human complement component C2.
3 Publications of Boster Complement C2 Antibodies & ELISA Kits
PubMed ID: 10.1038/s41401-021-00724-2, Identification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathwa...