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- Table of Contents
Caspase-1 Antibodies
AND CASP1 ELISA kits, Caspase-1 Proteins
Many biological assays use antibodies to detect Caspase-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Caspase-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Caspase-1 antibodies...
Designing a Western blot for Caspase-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CASP1 Western Blot GuideCASP1 Infographic by Boster Bio
All CASP1 Products
Product
Figures
Specificity
Applications
Price
Anti-Caspase-1(P20)/CASP1 Antibody Picoband®
30 Citations
Mouse, Rat
WB
$370
Cat # PA1440-1
100 μg/vial
Cat # PA1440-1
100 μg/vial
Anti-Caspase-12/CASP12 Antibody Picoband®
10 Citations
Human, Rat
IHC, WB
$370
Cat # PA2103
100 μg/vial
Cat # PA2103
100 μg/vial
Anti-Caspase-1 CASP1 Rabbit Monoclonal Antibody
23 Citations
Human, Rat
IHC, WB
$370
Cat # M00048
100 μl
Cat # M00048
100 μl
Human, Mouse, Rat
IP, WB
$370
Cat # M00048-2
100 μl/vial
Cat # M00048-2
100 μl/vial
Anti-Caspase-10/CASP10 Antibody Picoband®
1 Citations
Human
ELISA, Flow Cytometry, WB
$370
Cat # A02190-2
100 μg/vial
Cat # A02190-2
100 μg/vial
Anti-Caspase 1(p20)/CASP1 Antibody Picoband®
1 Citations
Human
ELISA, WB
$370
Cat # A00048-1
100 µg/vial
Cat # A00048-1
100 µg/vial
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02190
100 μl
Cat # M02190
100 μl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M05143
100 μl
Cat # M05143
100 μl
Human
Flow Cytometry, IP, IHC, WB
$370
Cat # M02190-1
100 μl
Cat # M02190-1
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00048-3
20μL, 40μL, 100μL, 200μL
Cat # M00048-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2284
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2284
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1083
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1083
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$405
Cat # A05143
100ul
Cat # A05143
100ul
Human
ELISA
$480
Cat # EKC1084
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1084
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00048S376
100ul
Cat # A00048S376
100ul
Enzyme Activity, SDS-PAGE
$243
Cat # PROTQ13427
Starting from 20ug
Cat # PROTQ13427
Starting from 20ug
CASP1 Overview
Facts about Caspase-1.
Caspase-1 (CASP1)
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine that is involved in many different inflammatory processes. Important for defense against pathogens.
Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | CASP1 |
| Uniprot: | P29466 |
| Entrez: | 834 |
Family
| Belongs to: |
|---|
| peptidase C14A family |
Alternative Names
CASP1; CASP-1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta; Caspase1; Caspase-1; EC 3.4.22; EC 3.4.22.36; ICE; ICEP45; IL-1 beta-converting enzyme; IL1BC CASP1 nirs variant 1; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1-B converting enzyme; interleukin 1-beta convertase; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
Molecular Weight
Mass (kDA):
45.159 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q22.3 |
| Sequence: | 11; NC_000011.10 (105025443..105035591, complement) |
Tissue Specificity
Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Subcellular Localizations
Cytoplasm. Cell membrane.
Diseases
- Inflammation
- Malignant Neoplasms
- Neoplasms
- Infective Disorder
- Cell Transformation, Neoplastic
- Carcinoma
- Salmonella Infections
- Malignant Neoplasm Of Breast
- Coronary Artery Disease
- Inflammatory Response
- Colorectal Cancer
- Innate Immune Response
- Immunologic Deficiency Syndromes
Interacting Proteins
- CARD17
- CARD18
- FGF2
- IL1A
- MEFV
- NLRC4
- NLRP1
- NOD2
- PYCARD
- VAC14
Pathways
- Cell Death
- Pathogenesis
- Secretion
- Immune Response
- Localization
- Cell Proliferation
- Inflammatory Response
- Pyroptosis
- Cell Cycle
- Innate Immune Response
- Cell Adhesion
- Cell Activation
- Dna Methylation
PTMs
- Cleavage
Research Areas
- Apoptosis
- Caspases
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP1
bosterbio.com/bosterbio-gene-info-cards/CASP1
References
PMID: 1574116 by Thornberry N.A., et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
PMID: 1373520 by Cerretti D.P., et al. Molecular cloning of the interleukin-1 beta converting enzyme.
32 Publications of Boster Caspase-1 Antibodies & ELISA Kits
- PubMed ID: 10.1097/CEJ.0b013e3283431c08, Profile of protein expression of the colon cancer cell line SW480 with survivin/...
- PubMed ID: 10.1016/j.ecoenv.2021.113097, Synergistic effects of botanical curcumin-induced programmed cell death on the m...
- PubMed ID: -, Peng Yuan,Xifeng Sun,Xiao Liu,Georg Hutterer,Karl Pummer,Boris Hager,Zhangqun Ye...
- PubMed ID: 33681944, Yang L,Liu Y,Wang Y,Li J,Liu N. Azeliragon ameliorates Alzheimer‘s disease...
- PubMed ID: 33549657, Zhang XL,Huang WM,Tang PC,Sun Y,Zhang X,Qiu L,Yu BC,Zhang XY,Hong YX,He Y,Ge XQ....
- PubMed ID: 32758603, Yang R,Li Y,Mehmood S,Yan C,Huang Y,Cai J,Ji J,Pan W,Zhang W,Chen Y.Polysacchari...
- PubMed ID: 32952148, Fan X,Ma W,Zhang Y,Zhang L.P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinfl...
- PubMed ID: 30651819, Bone marrow stromal cells improved functional recovery in spinal cord injury rat...
- PubMed ID: 27581210, Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like infl...
- PubMed ID: 24013954, Zhao S, Xiong Z, Mao X, Meng D, Lei Q, Li Y, Deng P, Chen M, Tu M, Lu X, Yang G,...
- PubMed ID: 21625440, Ding Y, Zou J, Li Z, Tian J, Abdelalim S, Du F, She R, Wang D, Tan C, Wang H, Ch...
- PubMed ID: 25813065, Zhang D, Yan H, Hu Y, Zhuang Z, Yu Z, Hang C. J Stroke Cerebrovasc Dis. 2015 May...
- PubMed ID: 25761252, Peng K, Liu L, Wei D, Lv Y, Wang G, Xiong W, Wang X, Altaf A, Wang L, He D, Wang...
- PubMed ID: 21248471, Zhao Y, Wu S, Wu J, Jia P, Gao S, Yan X, Wang Y. Cancer Biol Ther. 2011 Jan 1;11...
- PubMed ID: 25747387, Liu N, Chen T, Wang X, Yang D, Xue B, Zhu H. Febs Lett. 2015 Apr 2;589(8):897-90...
- PubMed ID: 22647236, Shu Hf, Yu Sx, Zhang Cq, Liu Sy, Wu Kf, Zang Zl, Yang H, Zhou Sw, Yin Q. Brain D...
- PubMed ID: 25780423, Wang Xf, Qu Xq, Zhang Tt, Zhang Jf. Exp Ther Med. 2015 Apr;9(4):1283-1291. Epub ...
- PubMed ID: 23073807, Li M, Peng J, Song Y, Liang H, Mei Y, Fang Y. J Huazhong Univ Sci Technolog Med ...
- PubMed ID: 25657685, Wu Z, Wang L, Hou S. Neural Regen Res. 2012 Jul 5;7(19):1493-7. Doi: 10.3969/J.I...
- PubMed ID: 24935781, Chen A, Dang T, Wang S, Tang N, Liu Y, Wu W. Sci China Life Sci. 2014 Jul;57(7):...
- PubMed ID: 25206897, Yuan X, Sun Q, Ou Y, Wang S, Zhang W, Deng H, Wu X, Zhang L. Neural Regen Res. 2...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page