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Boster Bio Life Science Blog
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The August edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.
This month’s research publications investigate heart regeneration in zebrafish, the protection of adipose-derived stem cells against UVB-induced skin photoaging, the neuroprotective effect of Z. bungeanum pericarps, electroacupuncture treatment of visceral hypersensitivity, etc.
In addition, scientists explore the mechanisms of several disorders, such as intestinal barrier injury, alcohol-associated hepatocellular carcinoma, and activated astrocytes’ roles in chronic post-surgical pain (CPSP).
Scroll down to learn more about these new scientific discoveries.
p53 soform 113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis
Authors: Ye, S., Zhao, T., Zhang, W., Tang, Z., Gao, C., Ma, Z., Xiong, J.W., Peng, J...
Journal: Cell Death & DiseaseNeonatal mice and adult zebrafish can fully regenerate their hearts through proliferation of pre-existing cardiomyocytes. Previous studies have revealed that p53 signalling is activated during cardiac regeneration in neonatal mice and that hydrogen peroxide (H2O2) generated near the wound site acts as a novel signal to promote...
Cited Boster Product(s): Anti-HIF-1 Alpha/HIF1A Antibody Picoband™ (A00013-1)
...Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis mediated mitophagy impairment
Authors: Huang, Y., Zhou, J., Wang, S., Xiong, J., Chen, Y., Liu, Y., Xiao, T., Li, Y…
Journal: TheranosticsThe dysfunctional gut-kidney axis forms a vicious circle, which eventually becomes a catalyst for the progression of chronic kidney disease (CKD) and occurrence of related complications. However, the pathogenic factors of CKD-associated intestinal dysfunction and its mechanism remain elusive. We first identified the protein-bound uremic...
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In our July edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.
This month’s research publications examine different types of cancers, including ovarian cancer, breast cancer, colorectal cancer, etc. Scientists also delve into other research fields, such as intervertebral disc (IVD) degeneration, wound healing, and type 2 diabetes.
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Accumulation of advanced glycation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes
Authors: Kopytek, M., Ząbczyk, M., Mazur, P., Undas, A., & Natorska, J.
Journal: Cardiovascular DiabetologyAccumulation of advanced glycation end products (AGEs) leads to chronic glycation of proteins and tissue damage, particularly in patients with diabetes mellitus (DM). We aimed to evaluate whether increased accumulation of AGEs in patients with aortic stenosis (AS) and concomitant type 2 diabetes (DM) is associated with AS severity...
Cited Boster Product(s): Human Rage ELISA Kit PicoKine™ (EK0827)
Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer
Authors: Ha, D.H., Min, A., Kim, S., Jang, H., Kim, S.H., Kim, H.J., Ryu, H.S, Ku, J.L...
Journal: Scientific ReportsDue to its regulation of CDK1/2 phosphorylation, WEE1 plays essentially roles in the regulations of G2/M checkpoint and DNA damage response (DDR). WEE1 inhibition can increase genomic instability by inducing replication stress and G2/M checkpoint inactivation, which result in increased cellular sensitivity to DNA damaging agents...
Cited Boster Product(s): Anti-Phospho-Cdc2 (Tyr15) CDK1 Antibody (P00209)
...Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation
Authors: Zhao, Y., Qiu, C., Wang, W., Peng, J., Cheng, X., Shangguan, Y., Xu, M., Li, J...
Journal: TheranosticsBackground: Intervertebral disc (IVD) degeneration is a common degenerative disease that can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy in patients. Methods: NP tissue and cells were isolated from patients and mice, and the expression profile of cortistatin (CST) was analysed. In addition...
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The June edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.
This month’s selected research publications investigate several cancers and diseases, including hepatocellular carcinoma, hepatitis B, prostate cancer, ankylosing spondylitis, rheumatoid arthritis, and diabetes.
Among the studies, scientists propose a prodrug for inflammatory diseases as well as a tumor nanovaccine that utilizes electrostatic interactions. The relationship of depression with inflammation and metabolic dysfunction in addition to ketamine’s potential anti-depressive effects are also explored.
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A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions
Authors: Lu, M., Zhang, X., Zhao, J., You, Q., & Jiang, Z.
Journal: Redox BiologyTranscription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (Keap1), control the redox and metabolic homeostasis and oxidative stress. Inhibitors of Keap1-Nrf2 interaction are promising in oxidative stress related inflammatory diseases but now hit hurdles. By utilizing...
Cited Boster Product(s): Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394); Mouse IL-6 ELISA Kit PicoKine™ (EK0411); Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527)
...The immunoglobulin superfamily member 3 (IGSF3) promotes hepatocellular carcinoma progression through activation of the NF-κB pathway
Authors: Sheng, P., Zhu, H., Zhang, W., Xu, Y., Peng, W., Sun, J., Gu, M., & Jiang, H.
Journal: Annals of Translational MedicineBackground: Patients with hepatocellular carcinoma (HCC) suff
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Our April edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.
This month's selected research publications cover disease areas from acute liver injury to hepatocellular carcinoma to silocosis. The papers also investigate pretreatment TRL, ZBP1 biological function, triclocarban exposure, and several other research topics.
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In our March edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.
Scroll down to learn more about these new scientific discoveries.
Berberine prevents primary peritoneal adhesion and adhesion reformation by directly inhibiting TIMP-1
Authors: Liu, X., Wei, Y., Bai, X., Li, M., Li, H., Wang, L., Zhang, S., Li, X., Zhao, T...
Journal: Acta Pharmaceutica Sinica BPeritoneal adhesions are fibrous tissues that tether organs to one another or to the peritoneal wall and represent the major cause of postsurgical morbidity. Enterolysis at repeat surgeries induces adhesion reformation that is more difficult to prevent than primary adhesion. Here we studied the preventive effects of different approaches of berberine...
Cited Boster Product(s): Human TIMP-1 ELISA Kit PicoKine™ (EK0520); Human MMP-3 ELISA Kit PicoKine™ (EK0461); Human MMP-8 ELISA Kit PicoKine™ (EK0464)
Tracing tumorigenesis in a solid tumor model at single-cell resolution
Authors: Praktiknjo, S.D., Obermayer, B., Zhu, Q., Fang, L., Liu, H., Quinn, H...
Journal: Nature CommunicationsCharacterizing the complex composition of solid tumors is fundamental for understanding tumor initiation, progression and metastasis. While patient-derived samples provide valuable insight, they are heterogeneous on multiple molecular levels, and often originate from advanced tumor stages. Here, we use single-cell transcriptome...
Cited Boster Product(s): Anti-Kallikrein 1/KLK1 Antibody (PA1709)
CCL3/CCR1 mediates CD14+CD16− circulating monocyte recruitment in knee osteoarthritis progression
Authors: Zhao, X., Gu, M., Xu, X., Wen, X., Yang, G., Li, L., Sheng, P., & Meng, F.
Journal: Osteoarthritis and CartilageObjectives: Monocyte-derived macrophages, as the predominant immune cell type that is increased in inflamed synovium, play a vital role during knee osteoarthritis (KOA) progression. However, the mechanisms underlying the recruitment of circulating monocytes to osteoarthritic knees remain uncertain. Based on previous data obtained from plasma...
Cited Boster Product(s): Human MCP-1 / CCL2 ELISA Kit PicoKine™ (EK0441); Human MIP-1Alpha/CCL3 ELISA Kit PicoKine™ (EK0448); Human CCL4/MIP-1 Beta ELISA Kit PicoKine™ (EK0450)
...Farrerol Directly Targets GSK-3β to Activate Nrf2-ARE Pathway and Protect EA.hy926 Cells against Oxidative Stress-Induced Injuries
Authors: Yan, C., Zhang, X., Miao, J., Yuan, H., Liu, E., Liang, T., & Li , Q.
Journal: Oxidative Medicine and Cellular LongevityOxidative stress-mediated endothelial injury is considered to be involved in the pathogenesis of various cardiovascular diseases. Farrerol, a typical natural flavanone from the medic
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The World Health Organization has declared COVID-19 as a pandemic. As COVID-19 spreads globally, communities are taking containment and mitigation steps while researchers are working hard to develop effective vaccines and treatments.
A recent research paper published in the journal Cell investigates how SARS-CoV-2, the virus that causes COVID-19, infects target cells through the interaction of...
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At Bosterbio, our customers’ research is our priority. Our mission is to help customers achieve their research goals so that they can stay on the cutting edge of research.
This February, we’d like to feature a selected number of recently published research from the scientists whom Boster has served.
Scroll down to see 10 research discoveries from different fields.
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Merry Christmas and Happy Holidays from all of us at Boster!
May peace, prosperity, and happiness be yours throughout the holidays and new year.
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Neuroscience 2019 is taking place October 19-23 at McCormick Place in Chicago. Join 30,000 scientists from around the world to discover hot topics and tools for neuroscience.
Stop by Boster’s Booth #1805 and pick up some pathway posters, technical resources, free phone accessories, and your very own Dr. Booster plush doll.
Come and learn about new techniques and resources that can benefit your research. See you this weekend!
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Boster will be attending 2 exciting events and we hope to see you there!
The NIH Research Festival is happening this week from September 11-13 at the Bethesda Campus. Meet us at Booth# 607 and pick up some great Boster gifts!
The Life Science Exhibits will be held next Thursday, September 19, at Houston Marriott at the Texas Medical Center. If you’re attending the exhibit, drop by to say hi!
Visit our booths to pick up some pathway posters, technical resources, free phone accessories, and your very own Dr. Booster plush doll.
Come and discover new techniques and resources that can benefit your research. See you soon!
Primary Antibodies
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Get better results with Boster!
Boster takes great measures to ensure product quality and to provide our customers with comprehensive data upfront. Our antibodies are validated using WB, IHC, and flow cytometry against a panel of over 250 tissues and un-transfected cell lines to ensure high affinity and crystal-clear IHC stains. In addition, we also validate our antibodies in a quantitative fashion by testing them on known <
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