Boster Bio Life Science Blog

Valentine's Day is just around the corner! Check out our science-inspired eCards and share the love this February by sending them to your loved ones, friends, and colleagues.

Today is World Cancer Day. Each year, organizations and people from around the world unite on February 4th to raise awareness about cancer.

According to the American Cancer Society, cancer mortality had dropped 32% from 1991 to 2019. This decline is mostly attributed to decreases in smoking and advancements in early cancer detection and treatment.

Despite this reduction in cancer mortality, cancer remains as a major public health problem worldwide. Globally, 1 out of 6 deaths...

We’re excited to present our first Research Spotlight edition of 2022, which features the latest scientific innovations from researchers whom Boster has served.

In this issue, scientists explore the signaling mechanisms of GDF11 during aging, TAF7 during gene expression, OTUD1 in intestinal inflammatory diseases, and the m6Am mRNA in the regulation of obesity.

We’re excited to present our first Research Spotlight edition of 2022, which features the latest scientific innovations from researchers whom Boster has served.

In this issue, scientists explore the signaling mechanisms of GDF11 during aging, TAF7 during gene expression, OTUD1 in intestinal inflammatory diseases, and the m6Am mRNA in the regulation of obesity.

We have also highlighted several studies discussing novel strategies in nanomedicine to help advance modern healthcare, inc...

As of January 2022, there are nearly 2,500 brain-derived neurotrophic factor (BDNF) antibodies to choose from according to CiteAb. In this article, I will share how I found the BDNF antibody that worked for my projects and I hope my experience is helpful if you are currently searching for good BDNF antibodies. I will also discuss the expected BDNF molecular weight in Western blots, BDNF positive and negative control designs, and a step-by-step guide of how I currently search for antibodies.

During my first year in the lab, my team was investigating BDNF’s role in Rett syndrome by treating various CNS cells with inflammatory cytokines in vitro and we discovered upregulation of BDNF mRNAs. Since we had to conduct protein level analysis, I started the hunt for anti-BDNF antibodies.

Almost any scientist who has worked with antibodies knows that many unexpected issues can occur even for the most well-known biomarkers and established antibodies. To prepare for the antibody search, I generally get 2 facts sorted out first:

1. The expected molecular weight the biomarker has in Western blotting
2. The tissues/cells known to express or not express the b
...

In our last edition of Research Spotlight this year, we're happy to feature 10 recent publications from scientists whom Boster has served.

Among the studies, scientists investigate the mechanisms of m6a reader for colorectal cancer, the anti-metastatic roles of dsRNA mimics, and the effects of USP12 on breast cancer angiogenesis.

In addition, scientists explore Vitamin D3's antioxidative stress ability as well as the lungfish cocoon's antimicrobial functions. Researchers also develop pitavastatin-loaded multilayer films that enhance osseointegration of metal implants.

Scroll down to find out more about these discoveries!

Our November edition of Research Spotlight highlights 10 research studies that provide deeper insights on the biological functions of several key biomarkers and their clinical translational potential.

Two studies reveal new insights for diabetes treatment by investigating the functions of PGRMC1 and an m6A reader protein for insulin metabolism and delayed diabetic wound healing respectively.

Scientists also perform bioinformatics and immunological analysis of several regulatory...

We're delighted to bring you our October edition of Research Spotlight, featuring 10 new publications of various fields from scientists whom Boster has served.

This month, research papers delve into nanotechnology advancements using polydopamine nanoparticles, PLGA nanoparticles, and HA-coated collagen nanofibers for cancer treatments and regenerative medicine.

Scientists also investigate how exercise can ameliorate tumor-associated anemia, how the SARS-CoV-2...

The September edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.

This month’s selected research papers characterize the underlying mechanisms of several cancers, HIV, and other systemic diseases. Among the studies, monoclonal antibodies and a tumor nanovaccine are explored as therapeutic treatments for different cancers.

Scientists also demonstrate how a 3D-printed biphasic scaffold can enhance cartilage regeneration. In addition, the role of PEDF in collagen synthesis and its implications for tissue expansion in plastic surgery is investigated.

Keep scrolling to find out more about these research studies.

Characterizing Dedifferentiation of Thyroid Cancer by Integrated Analysis

Authors: Luo, H., Xia, X., Kim, G.D., Liu, Y., Xue, Z., Zhang, L., Shu, Y., Yang, T...
Journal: Science Advances

Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and...

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Cited Boster Product(s): Anti-Vimentin Antibody Picoband™ (PB9359); Anti-E Cadherin 1/CDH1 Antibody Picoband™ (PB9561)

Oral Immune Dysfunction is Associated with the Expansion of FOXP3+PD-1+Amphiregulin+ T Cells During HIV Infection

Authors: Bhaskaran, N., Schneider, E., Faddoul, F., da Silva, A.P., Asaad, R...
Journal: Nature Communications

>Residual systemic inflammation and mucosal immune dysfunction persist in people living with HIV, despite treatment with combined anti-retroviral therapy, but the underlying immune mechanisms are poorly understood. Here we report that the altered immune landscape of the oral mucosa of HIV-positive patients on therapy involves...

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Cited Boster Product(s): Human CD14 ELISA Kit PicoKine™ (EK0694); Human TLR2/Toll-Like Receptor 2 ELISA Kit PicoKine™ (EK0906); Human Cotinine ELISA Kit (Competitive EIA) (EK7035); Human Amphiregulin(AR) / AREG ELISA Kit PicoKine™ (EK0304); Human IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0392); Human IL-6/Interleukin-6 ELISA Kit PicoKine™ (EK0410)

Increased Plasmin-Mediated Proteolysis of L1CAM in a Mouse Model of idiopathic Normal Pressure Hydrocephalus

Authors: Yang, D., Yang, H., Luiselli, G., Ogagan, C., Dai, H., Chiu, L...
Journal: PNAS (Proceedings of the National Academy of Sciences of the United States of America)

Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder that is characterized by enlarged cerebral ventricles, gait difficulty, incontinence, and dementia. iNPH usually develops after the sixth decade of life in previously asymptomatic individuals. We recently reported that loss-of-function deletions in CWH43...

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Cited Boster Product(s): Anti-Plasminogen Antibody Picoband™ (A03674-1)

Cooperating Minimalist Nanovaccine with PD-1 Blockade for Effective and Feasible Cancer Immunotherapy

Authors: Jiang, M., Zhao, L., Cui, X., Wu, X., Zhang, Y., Guan, X., Ma, J...
Journal: Journal of Advanced Research

Introduction: Tumor vaccine has been a research boom for cancer immunotherapy, while its therapeutic outcome is severely depressed by the vulnerable in vivo delivery efficiency. Moreover, tumor immune escape is also another intractable issue, which has badly whittled down the therapeutic efficiency. Objectives: Our study aims to solve...

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Cited Boster Product(s): FITC Conjugated Avidin (BA1125)

Our August edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.

In this month’s edition, research studies delve into the behavioral and cognitive parts of the brain and investigate how various cytokine levels are associated with the progression of neurodegenerative disorders. A comprehensive evaluation of the efficacy and safety of using stem cell therapy for traumatic brain injury is also discussed.

Researchers explore additional...

In the July edition of Research Spotlight, we hand-picked a range of scientific publications that investigate several new approaches to control the development of chronic and morbid diseases without systemic side effects.

Among the studies, researchers discuss how modulations of IL-1β-primed ERCs, IL-23, Lnc-408, and LncRNA CERS6-AS1 levels could alleviate the pathological damages of ulcerative colitis, breast cancer, and pancreatic cancer respectively. Associations between prenatal acrylamide exposure with decreased fetal growth are also further explored.

Scroll down to learn about new drug delivery platforms and therapies, and discover more about the immune response towards diseases.

IL-1β Pre-Stimulation Enhances the Therapeutic Effects of Endometrial Regenerative Cells on Experimental Colitis

Authors: Yu, D., Zhao, Y., Wang, H., Kong, D., Jin, W., Hu, Y., Qin, Y…
Journal: Stem Cell Research & Therapy

Background: Ulcerative colitis (UC) is a chronic, relapsing, and non-specific inflammatory bowel disease, and the current treatment strategies were mainly used to relieve symptoms or for maintenance. Endometrial regenerative cells (ERCs) are mesenchymal-like stromal cells and have been demonstrated to alleviate multiple immune...

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Cited Boster Product(s): Anti-Mannose Receptor/MRC1 Picoband™ Antibody (A02285-2); Mouse IFN Gamma ELISA Kit PicoKine™ (EK0375); Mouse IL-17 ELISA Kit PicoKine™ (EK0431); Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-6 ELISA Kit PicoKine™ (EK0411); Mouse IL-4 ELISA Kit PicoKine™ (EK0405); Mouse IL-10 ELISA Kit PicoKine™ (EK0417)