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Boster Bio Life Science Blog
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This month, we share some of the latest research studies that explore the underlying mechanisms in disease progressions investigated by scientists whom Boster has served.
Our May edition of Research Spotlight includes a mix of topics about myopia, breast cancer, DNA damage, and inflammatory response progressions. Find out more about the essential roles of several compounds and novel treatments in modulating the responses of signalling pathways.
Scroll down to learn more about these new scientific discoveries.
Aberrant TGF-β1 Signaling Activation by MAF Underlies Pathological Lens Growth in High Myopia
Authors: Zhu, X., Du, Y., Li, D., Xu, J., Wu, Q., He, W., Zhang, K., Zhu, J…
Journal: Nature CommunicationsHigh myopia is a leading cause of blindness worldwide. Myopia progression may lead to pathological changes of lens and affect the outcome of lens surgery, but the underlying mechanism remains unclear. Here, we find an increased lens size in highly myopic eyes associated with up-regulation of β/γ-crystallin expressions. Similar findings are replicated in two independent...
Cited Boster Product(s): Human TGF Beta 1 ELISA Kit PicoKine™ (EK0513)
Cu-Induced Spermatogenesis Disease is Related to Oxidative stress-Mediated Germ Cell Apoptosis and DNA Damage
Authors: Guo, H., Ouyang, Y., Wang, J., Cui, H., Deng, H., Zhong, X., Jian, Z…
Journal: Journal of Hazardous MaterialsCopper is considered as an indispensable trace element for living organisms. However, over-exposure to Cu can lead to adverse health effects on human. In this study, CuSO4 decreased sperm concentration and motility, increased sperm malformation rate. Concurrently, testicular damage including testicular histopathological aberrations...
Cited Boster Product(s): Goat Anti-Mouse IgG (H+L) Secondary Antibody, Biotin Conjugated (BA1001)
Light-Induced Dynamic RGD Pattern for Sequential Modulation of Macrophage Phenotypes
Authors: Luo, Y., Zheng, X., Yuan, P., Ye, X., Ma, L.
Journal: Bioactive MaterialsDue to the critical roles of macrophage in immune response and tissue repair, harnessing macrophage phenotypes dynamically to match the tissue healing process on demand attracted many attentions. Although there have developed many advanced platforms with dynamic features for cell manipulation, few studies have designed a dynamic...
Cited Boster Product(s): Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0527); Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0394); Mouse IL-10/Interleukin-10 ELISA Kit PicoKine™ (EK0417); Mouse TGF Beta 1 ELISA Kit PicoKine™ (EK0515)
VRK2 is Involved in the Innate Antiviral Response by Promoting Mitostress-Induced mtDNA Release
Authors: He, W.R., Cao, L.B., Yang, Y.L., Hua, D., Hu, M.M., Shu, H.B.
Journal: Cellular & Molecular ImmunologyMitochondrial stress (mitostress) triggered by viral infection or mitochondrial dysfunction causes the release of mitochondrial DNA (mtDNA) into the cytosol and activates the cGAS-mediated innate immune response. The regulation of mtDNA release upon mitostress remains uncharacterized. Here, we identified mitochondria-associated...
Cited Boster Product(s): Mouse CXCL10/IP-10 ELISA Kit PicoKine™ (EK0736)
LncRNA SNHG6 Promotes G1/S-Phase Transition in Hepatocellular Carcinoma by Impairing miR-204-5p-Mediated Inhibition of E2F1
Authors: Chen, K., Hou, Y., Liao, R., Li, Y., Yang, H., Gong, J.
Journal: OncogeneEmerging evidence suggests that long noncoding RNAs (lncRNAs) function as competitive endogenous RNA (ceRNA) targeting proteins and genes; however, the role of lncRNAs in hepatocellular carcinoma (HCC) is not well understood. We investigated the mechanism by which lncRNA SNHG6 promotes the development of HCC. RT-qPCR revealed...
Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100)
Exposure to Constant Light Impairs Cognition with FTO Inhibition and m6A-Dependent TrκB Repression in Mouse Hippocampus
Authors: Yang, Y., Feng, Y., Hu, Y., Liu, J., Shi, H., Zhao, R.
Journal: Environmental PollutionN6-methyladenosine (m6A) mRNA methylation plays a role in various brain functions. Exposure to chronic constant light (CCL) has been reported to impair cognition, yet whether the underlying mechanism involves m6A remains unknown. In this study, mice exposed to CCL for 3 weeks show impaired cognitive behavior, which was associated...
Cited Boster Product(s): HRP Conjugated Goat Anti-Mouse IgG SABC Kit (SA1021); HRP Conjugated Goat Anti-Rabbit IgG SABC Kit (SA1022)
...Increased Telomerase Activity in Major Depressive Disorder with Melancholic Features: Possible Role of Pro-Inflammatory Cytokines and the Brain-Derived Neurotrophic Factor
Authors: Çavuşoğlu, P.B., İscan, E., Güneş, A., Atabey, N., Alkın, T.
Journal: Brain, Behavior, & Immunity - HealthThe biological mechanisms responsible for depression symptoms are not yet understood. For this reason, it is important to reveal the etiopathogenetic mechanisms in this disease. This study aims to compare the levels of pro-inflammatory cytokines, Brain-Derived Neurotrophic Factor (BDNF), and telomerase activity in patients with major...
Cited Boster Product(s): Human IL-6
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Science is always evolving and advancing throughout the ongoing process of knowledge discovery. Every month, we select 10 recent publications from scientists whom Boster has served.
Our April edition of Research Spotlight presents the latest information about various tumor-regulating genes/proteins, including BRCA1, HMGB1, EGFR, VEGFR2, PERK, and lncRNA LOC102724169. Several promising strategies to modulate immunoinflammatory microenvironments for bone regeneration and cancer are also...
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In our March edition of Research Spotlight, we present 10 latest research papers from scientists whom Boster has served.
Scientists explore the roles of various pathways associated with tumor development, and how they may emerge as new therapeutic targets for tumor metastasis. Several research studies also reveal the active role of gut microbiota in immunity and disease progressions as well as the effect of several compounds on the functionality and ecology of gut microbiome.
Take a look below to learn more about these new research findings.
...Fecal Microbiota Transplantation in HIV: A Pilot Placebo-Controlled Study
Authors: Serrano-Villar, S., Talavera-Rodríguez, A., Gosalbes, M.J., Madrid, N...
Journal: Nature CommunicationsChanges in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio less than 1 randomized to either weekly fecal microbiota capsules or placebo for 8 weeks. Stool donors were rationally...
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We are delighted to announce Boster Bio has been named a winner of the 2021 Bioz Stars Award for Antibodies! We’re proud to be supporting scientists worldwide to advance their research since 1993.
Bioz Stars Awards are based on real-world measured successful product usage from over 33 million peer-reviewed scientific articles analyzed by Bioz’s patented AI technology. Winners are selected using data that generates objective product ratings and recommendations. Bioz’s AI platform exami...
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The February edition of Research Spotlight provides 10 recent research discoveries from scientists whom Boster has served, which include new insights on the interactions between nanoparticles and human health as well as the underlying mechanisms.
The pathology-improvement effects of siRNA-based drugs on lung disorders, trichostatin A on Alzheimer’s disease, and propofol on microglial phagocytosis were also explored.
Scroll down to find out more about each featured publication.
...Combined Exposure of Alumina Nanoparticles and Chronic Stress Exacerbates Hippocampal Neuronal Ferroptosis via Activating IFN-γ/ASK1/JNK Signaling Pathway in Rats
Authors: Zhang, H., Jiao, W., Cui, H., Sun, Q., & Fan, H.
Journal : Journal of Hazardous MaterialsAlumina nanoparticles (AlNPs) exposure causes hippocampal-dependent cognitive dysfunction. However, whether chronic stress exacerbates AlNPs-induced hippocampal lesion and its mechanism remains unclear. This study was aimed to investigate the combined effects and mechanisms of AlNPs and chronic stress on the hippocampal lesion. The...
Cited Boster Product(s): Rat TNF Alpha ELISA Kit PicoKine™ (EK0526); Rat IL-1
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Our January edition of Research Spotlight presents an array of 10 interesting developments in the biomedical world. Valuable information about proliferation of cancer cells, immunity, inflammatory bowel diseases, and the body’s responses to oxidative stress and various nutrients are discussed.
In addition, scientists investigate how SLC19A1 as the major transporter of CDNs into cells could serve as a new potential immunotherapeutic treatment of cancer and some inflammatory diseases...
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The December edition of Research Spotlight highlights 10 recent research discoveries from scientists whom Boster has served.
In these studies, the effects of several key proteins and their signaling pathways were explored in correlation to the progression and activation of cancer cells, diabetic nephropathy, inflammation, and brain injury.
The role of polysulfides as potential tumor suppressors and regulators might represent an alternative therapeutic candidate for the management of diabetic nephropathy. Additionally, several promising potential therapeutic strategies for enhanced immunotherapy, such as enhanced drug delivery systems, ultrasound-guided platelet-rich plasma injection, and the role of mechanical cues in vascular biology were also investigated.
Scroll down to find more information about these new scientific discoveries.
Polysulfide-Mediated Sulfhydration of SIRT1 Prevents Diabetic Nephropathy by Suppressing Phosphorylation and Acetylation of p65 NF-κB and STAT3
Authors: Sun, H.J., Xiong, S.P., Cao, X., Cao, L., Zhu, M.Y., Wu, Z.Y., & Bian, J.S.
Journal: Redox BiologyDiabetic kidney disease is known as a major cause of chronic kidney disease and end stage renal disease. Polysulfides, a class of chemical agents with a chain of sulfur atoms, are found to confer renal protective effects in acute kidney injury. However, whether a polysulfide donor, sodium tetrasulfide (Na2S4), confers protective...
Cited Boster Product(s): Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394); Mouse VCAM-1 ELISA Kit PicoKine™ (EK0538)
...Development of Thermosensitive Resiquimod-Loaded Liposomes for Enhanced Cancer Immunotherapy
Authors: Zhang, H., Tang, W.L., Kheirolomoom, A., Fite, B.Z., Wu, B., Lau, K...
Journal: Journal of Controlled ReleaseResiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and immunostimulatory activity. Howeve
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In our November edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.
This month’s selected research publications investigate how several cells and mediators regulate the development of fibrotic diseases, cancer, inflammatory responses, diabetes, allergy, endometriosis, and anxiety.
Among the studies, scientists propose the underlying mechanisms of how endothelin receptor antagonists may serve as a therapeutic strategy for fibrotic diseases. The role of PRMT5 in laryngeal tumor carcinogenesis is also explored.
Discover more details about these new scientific discoveries below.
...Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies
Authors: Hughes, T.K., Wadsworth, M.H., Gierahn, T.M., Do, T., Weiss, D...
Journal: ImmunityHigh-throughput single-cell RNA-sequencing (scRNA-seq) methodologies enable characterization of complex biological samples by increasing the number of cells that can be profiled contemporaneously. Nevertheless, t
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The October edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.
This month’s research publications examine treatments and mechanisms for cancers such as breast cancer, colitis-associated cancer, and ovarian cancer. Scientists also propose stem cell derived biomimetic vesicles for versatile and effective targeted delivery. In addition, researchers investigate how dihydroartemisinin (DHA) can ameliorate psoriatic skin inflammation.
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...GSH Depletion Liposome Adjuvant for Augmenting the Photothermal Immunotherapy of Breast Cancer
Authors: Zhou, Z., Wu, H., Yang, R., Xu, A., Zhang, Q., Dong, J., Qian, C., & Sun, M.
Journal: Science AdvancesThe high redox level of tumor microenvironment inhibits the oxidation treatment and the immune response. Here, we innovatively develop maleimide liposome (ML) adjuvants to promote immunogenic cell death (ICD) induction and dendritic cells (DCs) maturation by glutathione (GSH) depletion for augmenting the photothermal immunotherapy...
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In our September edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.
This month’s selected research publications examine the mechanisms of plaque rupture, ELABELA in DOCA/salt-induced hypertension, BMSC-derived exosomes in peripheral nerve regeneration, TMZ in diabetic nephropathy, and MCL on LPS-induced inflammation.
Among the studies, scientists also investigate nanomicelle’s effect on paclitaxel’s immune-activation ability. In addition, the connection of cancer-associated SNPs in lncRNA for lung cancer and the role of IL-6 for colorectal cancer are explored.
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...Nanomicelle protects the immune activation effects of Paclitaxel and sensitizes tumors to anti-PD-1 Immunotherapy
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