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Aspartoacylase Antibodies

AND ASPA ELISA kits, Aspartoacylase Proteins

Many biological assays use antibodies to detect Aspartoacylase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aspartoacylase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aspartoacylase antibodies...

We validate the specificity of these antibodies to Aspartoacylase by testing them on tissues known to express ASPA positively and negatively. Browse below to find the ASPA antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ASPA Infographic by Boster Bio

ASPA protein infographic

All ASPA Products

Product

Figures

Specificity

Applications

Price

Anti-Aspartoacylase ASPA Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A04962
100ul

Human ASPA Recombinant Protein

SDS-PAGE

$265
Cat # PROTP45381
Starting from 20ug

Anti-ASPA Mouse Monoclonal Antibody [Clone ID: OTI3G5]

Human, Mouse, Rat

IHC, WB

$523
Cat # M04962
100 µl

ASPA Overview

Facts about Aspartoacylase.

ASPA 3D structure

ASPA 3D structure. Source: alphafold

Aspartoacylase (ASPA)

Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant role in the maintenance of intact white matter.

In other cells it act as a scavenger of NAA in body fluids. .

Gene Information

Human
Gene Name:	ASPA
Uniprot:	P45381
Entrez:	443

Gene Information

Family

Belongs to:

AspA/AstE family

Family

Alternative Names

ACY-2; ACY2aminoacylase 2; Aminoacylase-2; ASPaminoacylase-2; aspartoacylase (aminoacylase 2, Canavan disease); aspartoacylase; EC 3.5.1.15

Molecular Weight

Mass (kDA):
35.735 kDA

Molecular Weight

Genomic Context


Human

Location:	17p13.2
Sequence:	17; NC_000017.11 (3473646..3503405)

Tissue Specificity

Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver.

Subcellular Localizations

Cytoplasm. Nucleus.

Subcellular Localization

Diseases

Canavan Disease
Leukodystrophy
Neurodegenerative Disorders
Nervousness
Spongy Degeneration
Macrocephaly
Muscle Hypotonia
Epilepsy
Malignant Neoplasms
Developmental Delay (disorder)
Yersinia Pseudotuberculosis Infections

Yersinia Infections
Atrophy
Malnutrition
Neoplasms
Gastroenteritis

Disease

Interacting Proteins

ACY3
DUPD1
KEAP1

Interacting Proteins

Pathways

Myelination
Pathogenesis
Localization
Excretion
Virulence
Transport
Anaerobic Respiration
Oligodendrocyte Differentiation
Tricarboxylic Acid Cycle
Brain Development
Proteolysis
Swimming Behavior
Cell Division

Sensitization
Swimming
Cell Cycle
Cell Differentiation
Histone Acetylation
Cell Communication
Mating

Pathways

PTMs

Deacetylation
Nitration
Acetylation

Cleavage
Carboxylation
Deamination

Amination

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASPA

References

PMID: 8252036 by Kaul R., et al. Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease.

PMID: 12706335 by Moore R.A., et al. Purification and preliminary characterization of brain aspartoacylase.