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- Table of Contents
Klotho Antibodies
AND KL ELISA kits, Klotho Proteins
Many biological assays use antibodies to detect Klotho, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Klotho in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Klotho antibodies...
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KL Infographic by Boster Bio
All KL Products
Product
Figures
Specificity
Applications
Price
Human Klotho ELISA Kit PicoKine®
2 Citations 7 Q&As
Human
ELISA
$750
Cat # EK1688
96 wells/kit, with removable strips.
Cat # EK1688
96 wells/kit, with removable strips.
KL Overview
Facts about Klotho.
Klotho (KL)
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be dormant as a glycosidase in vivo.
May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of vitamin D (By similarity). Essential element for the particular interaction between FGF23 and FGFR1 (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | KL |
| Uniprot: | Q9UEF7 |
| Entrez: | 9365 |
Family
| Belongs to: |
|---|
| glycosyl hydrolase 1 family |
Alternative Names
EC 3.2.1; EC 3.2.1.31; KL; Klotho
Molecular Weight
Mass (kDA):
116.181 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q13.1 |
| Sequence: | 13; NC_000013.11 (33016063..33066143) |
Tissue Specificity
Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Isoform 1 shedding leads to a soluble peptide.; [Isoform 2]: Secreted.; [Klotho peptide]: Secreted.
Diseases
- Degenerative Polyarthritis
- Osteoarthritis, Knee
- Pneumonia
- Neoplasms
- Pain
- Malignant Neoplasms
- Tissue Adhesions
- Inflammation
- Leukemia
- Carcinoma
- Knee Pain
- Staphylococcal Infections
Pathways
- Aging
- Cell Proliferation
- Cell Growth
- Localization
- Secretion
- Transport
- Cell Development
- Cell Cycle
- Oocyte Growth
- Segmentation
- Pathogenesis
- Cell Adhesion
- Cell Differentiation
PTMs
- Phosphorylation
- Cleavage
- Oxidation
- Methylation
- Glycosylation
- Demethylation
- Carboxylation
- Dephosphorylation
- Ribosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KL
bosterbio.com/bosterbio-gene-info-cards/KL
References
PMID: 9363890 by Kuro-o M., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PMID: 9464267 by Matsumura Y., et al. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein.
1 Publications of Boster Klotho Antibodies & ELISA Kits
- PubMed ID: 10.1155/2021/1697070, Exercise-Linked Irisin Prevents Mortality and Enhances Cognition in a Mice Model...
*More publications can be found for each product on its corresponding product page