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Facts about Klotho.
May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of vitamin D (By similarity). Essential element for the particular interaction between FGF23 and FGFR1 (By similarity).
Human | |
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Gene Name: | KL |
Uniprot: | Q9UEF7 |
Entrez: | 9365 |
Belongs to: |
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glycosyl hydrolase 1 family |
EC 3.2.1; EC 3.2.1.31; KL; Klotho
Mass (kDA):
116.181 kDA
Human | |
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Location: | 13q13.1 |
Sequence: | 13; NC_000013.11 (33016063..33066143) |
Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Isoform 1 shedding leads to a soluble peptide.; [Isoform 2]: Secreted.; [Klotho peptide]: Secreted.
This article will provide a quick overview of the best uses for Boster Bio's Anti-MUC1 / EMA / CD227 (Epithelial Marker) Monoclonal Antibody. Read on to find out why this antibody is a must-have for your research. Monoclonal antibodies have many benefits. Continue reading to learn more.
Boster Bio Anti-CD34 Antibody is available for testing on multiple platforms like IHC-P. ICC. WB. It has been tested on Rat, Mouse, and Human. Boster offers product credits to scientists that are the first to review their product. They express their gratitude to these scientists. It is also available to purchase.
Potential drug development candidates include the CDC-28 peptide. Also known as KL Marker. It may be involved in hematopoiesis, acting as a scaffold to lineage specific glycos. It may also contain carbohydrate ligands that can be used to selectins. Boster Bio Anti CD34 Antibody has been validated on multiple platforms, including positive and negative samples.
This product is a fully human-recombinant antibodi that targets the junction of MUC1 subunits a and b. Antibodies against this peptide have a higher affinity than those against the VNTR region of MUC1.
Combining TAB004 treatment with Lip-MSAIL-2 treatment slowed PanIN lesion progression to adenocarcinoma. This antibody boosted tumor specific CD45+CD11b+ cells and decreased serum MPO and IL-5 levels. It also inhibited the growth immune-suppressive tMUC1.
The EMA/CD227 molecule has high affinity for human immune cells, enabling it to recognize a variety of cancer-associated mucins. Mucins are expressed exclusively by glandular epithelial cells, and therefore their antigen-binding activity may be beneficial in the treatment of cancer.
The MUC1 molecule is expressed in glandular tissues of the adrenal gland and in the cervix, and in the uterus and fallopian tubes. The antibody can also detect in the salivary gland, testis seminiferous and testis ducts. The MUC1 / EMA /CD227 monoclonal antibodies are also useful for cancer screening.
Hypoglycosylation of cancer cells is demonstrated by the MUC1 molecule. It is expressed in cancer cells up to 10 times more than normal cells. This makes it a powerful biomarker for the development and testing of new cancer therapies. Antibodies that target tumor-associated MUC1 could be more effective than antibodies that target normal cells. This is because the target will latch onto tumor-associated MUC1 more than normal cells.
The anti EMA vs. CD227 (Epithelial markers) monoclonal anti-MUC1 & EMA monoclonal antibodies is used for advanced measurable, or evaluable, pancreatic cancer patients. OncoVent Co., Ltd., is conducting a phase I/II clinical trial of this product for pancreatic cancer in the US.
Mucin is a high-molecular-weight glycoprotein that lubricates the surface of epithelial cells and protects them against invading pathogens. Two types of mucins are broadly classified, membrane-bound mucins (secretory gel-forming mucins) and one type (mucin). The secretory-gel-forming mucins exhibit a transmembrane architecture and an extracellular region at their N'terminal end. Both types are important in cell signaling pathways and cellular interaction.
Boster Bio can accept your results for further research if you have an application, a special sample, or species. Boster Bio will provide product credits and support throughout the study. And all this is applicable to scientists around the world. Get a Boster Bio Anti–MUC1/EMA /CD227 (Epithelial marker), monoclonal antibodies today!
TAB004 is an antimUC1/EMA & cd227 (epithelial marker). This antibody can reduce the blood neutrophil/lymphocyte ratio and improve the outcome of cancer patients. Lip-MSA-2IL-2 combined treatment has shown promising results.
This product can also be used to target MUC1 or EMA. It is also useful in regulating IL-6 production which plays a crucial role in cancer prevention and innate immunity. It inhibits the expression of CXCL1, a prominent target in clinical trials. The combination therapy may also promote wound healing, macrophage/monocyte recruitment, and wound healing.
PMID: 9363890 by Kuro-o M., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PMID: 9464267 by Matsumura Y., et al. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein.
*More publications can be found for each product on its corresponding product page