AND GALE ELISA kits, UDP-glucose 4-epimerase Proteins
Many biological assays use antibodies to detect UDP-glucose 4-epimerase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UDP-glucose 4-epimerase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UDP-glucose 4-epimerase antibodies...
We validate the specificity of these antibodies to UDP-glucose 4-epimerase by testing them on tissues known to express GALE positively and negatively. Browse below to find the GALE antibody that suites your experiment. We have 81 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Catalyzes two different but analogous responses: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The response with UDP-Gal plays a crucial role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate.
It contributes to the catabolism of dietary galactose and empowers the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous resources are limited. The two UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Gene Information
Human
Gene Name:
GALE
Uniprot:
Q14376
Entrez:
2582
Family
Belongs to:
NAD(P)-dependent epimerase/dehydratase family
Alternative Names
EC 5.1.3; EC 5.1.3.2; FLJ95174; FLJ97302; Galactowaldenase; short chain dehydrogenase/reductase family 1E, member 1; UDP galactose-4'-epimerase; UDP-; UDP-galactose 4-epimerase; UDP-galactose-4-epimerase; UDP-glucose 4-epimerase
Molecular Weight
Mass (kDA): 38.282 kDA
Genomic Context
Human
Location:
1p36.11
Sequence:
1; NC_000001.11 (23795599..23800754, complement)
Diseases
Udpglucose 4-epimerase Deficiency Disease
Salmonella Infections
Classical Galactosemia
Deficiency Of Galactokinase
Galactosemias
Influenza
Tissue Adhesions
Deficiency Of Epimerase
Typhoid Fever
Malignant Neoplasms
Diabetes Mellitus, Insulin-dependent
Inborn Errors Of Metabolism
Cell Invasion
Guillain-barre Syndrome
Pneumonia
Cholera
Abscess
Cancer Patients And Suicide And Depression
Meningococcal Infections
Group B Streptococcal Infection
Pathways
Virulence
Transport
Translation
Glycosylation
Biofilm Formation
Localization
Cell Proliferation
Pathogenesis
Excretion
Immune Response
Nodulation
Locomotion
Colony Morphology
Cell Division
Nitrogen Fixation
Lactose Transport
Germination
Proteolysis
Complement Activation
Seed Germination
PTMs
Glycosylation
Methylation
Deglycosylation
Phosphorylation
Cleavage
Oxidation
Nitration
Dephosphorylation
Research Areas
Lipid and Metabolism
For details, visit: bosterbio.com/bosterbio-gene-info-cards/GALE
References
PMID: 8593531 by Daude N., et al. Molecular cloning, characterization, and mapping of a full-length cDNA encoding human UDP-galactose 4'-epimerase.
PMID: 9538513 by Maceratesi P., et al. Human UDP-galactose 4'epimerase (GALE) gene and identification of five missense mutations in patients with epimerase deficiency galactosemia.
44 Publications of Boster UDP-glucose 4-epimerase Antibodies & ELISA Kits
PubMed ID: PMID:30210685, Collagen type V a2 (COL5A2) is decreased in steroid-induced necrosis of the femo...
PubMed ID: 10.3892/etm.2019.7227, Expression of galectin‑3 and apoptosis in placental villi from patients with m...
PubMed ID: 10.3390/toxins12050330, Neuroprotective Fragment C of Tetanus Toxin Modulates IL-6 in an ALS Mouse Model
PubMed ID: 10.3390/diagnostics11112101, The Interplay between Myocardial Fibrosis, Strain Imaging and Collagen Biomarker...
PubMed ID: 10.3390/cancers12082218, Autocrine Signaling of NRP1 Ligand Galectin-1 Elicits Resistance to BRAF-Targete...