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- Table of Contents
Caspase-3 Antibodies
AND CASP3 ELISA kits, Caspase-3 Proteins
Many biological assays use antibodies to detect Caspase-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Caspase-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Caspase-3 antibodies...
Designing a Western blot for Caspase-3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CASP3 Western Blot GuideCASP3 Infographic by Boster Bio
All CASP3 Products
Product
Figures
Specificity
Applications
Price
Anti-Caspase-3/CASP3 Antibody Picoband®
85 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # PB9188
100 μg/vial
Cat # PB9188
100 μg/vial
Anti-Caspase-3 (P10)/CASP3 Antibody Picoband®
15 Citations
Human
IHC, ICC, WB
$370
Cat # PA1302-1
100 μg/vial
Cat # PA1302-1
100 μg/vial
Human Caspase 3/CASP3 ELISA Kit PicoKine®
8 Citations
Human
ELISA
$499
Cat # EK1425
96 wells/kit, with removable strips.
Cat # EK1425
96 wells/kit, with removable strips.
Anti-Caspase-3 p12 CASP3 Rabbit Monoclonal Antibody
37 Citations
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00334-2
100 μl
Cat # M00334-2
100 μl
Anti-Caspase 3 Rabbit Monoclonal Antibody
35 Citations
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M00334-9
100 μl/vial
Cat # M00334-9
100 μl/vial
Anti-Caspase-3 CASP3 Rabbit Monoclonal Antibody
27 Citations
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00334-5
100 μl
Cat # M00334-5
100 μl
Anti-pro Caspase 3 CASP3 Rabbit Monoclonal Antibody
26 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00334
100 μl
Cat # M00334
100 μl
Anti-Caspase-3(P17)/CASP3 Antibody Picoband®
5 Citations
Mouse, Rat
IHC, WB
$370
Cat # PA1961-1
100 μg/vial
Cat # PA1961-1
100 μg/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00334-7
100 μg/vial
Cat # M00334-7
100 μg/vial
Anti-Caspase-3(p17)/CASP3 Antibody Picoband®
6 Citations
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # A00334-2
100 μg/vial
Cat # A00334-2
100 μg/vial
Human
IF, IHC, ICC, WB
$370
Cat # M00334-3
100 μl
Cat # M00334-3
100 μl
Human, Mouse
IHC, WB
$370
Cat # M00349-3
100 μg/vial
Cat # M00349-3
100 μg/vial
Human
Flow Cytometry, IHC, WB
$370
Cat # M00334-6
100 μg/vial
Cat # M00334-6
100 μg/vial
Human
ELISA
$500
Cat # EZ1425
5 plates/kit
Cat # EZ1425
5 plates/kit
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M00334-4
100 μl
Cat # M00334-4
100 μl
Human
ELISA
$499
Cat # FEK1425
96 wells/kit, with removable strips.
Cat # FEK1425
96 wells/kit, with removable strips.
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00334-1
100 μl
Cat # M00334-1
100 μl
Anti-Caspase 3/CASP3 Antibody Picoband®
1 Citations
Human, Mouse, Rat
WB
$370
Cat # PA1849
100 μg/vial
Cat # PA1849
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00334-10
20μL, 40μL, 100μL, 200μL
Cat # M00334-10
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00334-11
20μL, 40μL, 100μL, 200μL
Cat # M00334-11
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00334S150
100ul
Cat # A00334S150
100ul
Human, Mouse, Rat
ELISA
$540
Cat # EKC2227
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2227
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1086
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1086
1 kit, containing one 96-well plate and all necessary reagents
Enzyme Activity, SDS-PAGE
$346
Cat # PROTP42574
Starting from 10ug
Cat # PROTP42574
Starting from 10ug
CASP3 Overview
Facts about Caspase-3.
Caspase-3 (CASP3)
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) in a'216-Asp-.
Gene Information
| Human | |
|---|---|
| Gene Name: | CASP3 |
| Uniprot: | P42574 |
| Entrez: | 836 |
Family
| Belongs to: |
|---|
| peptidase C14A family |
Alternative Names
Apopain; apoptosis-related cysteine protease; CASP3; CASP-3; caspase 3, apoptosis-related cysteine peptidase; Caspase3; Caspase-3; CPP32; CPP-32; CPP32B; CPP32SREBP cleavage activity 1; Cysteine protease CPP32; EC 3.4.22; EC 3.4.22.56; LICE-1; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; YAMA
Molecular Weight
Mass (kDA):
31.608 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q35.1 |
| Sequence: | 4; NC_000004.12 (184627696..184649475, complement) |
Tissue Specificity
Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Carcinoma
- Ischemia
- Inflammation
- Nerve Degeneration
- Neuroblastoma
- Liver Carcinoma
- Alzheimer's Disease
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Neurodegenerative Disorders
Interacting Proteins
- AKAP8
- AKT3
- CASP6
- CASP9
- MDM2
- NMT2
- PARP1
- TXN
- WNK3
- XIAP
Pathways
- Cell Death
- Induction Of Apoptosis
- Cell Cycle
- Cell Proliferation
- Programmed Cell Death
- Cell Growth
- Pathogenesis
- Apoptotic Process
- Proteolysis
- Cell Cycle Arrest
- Localization
- Neuroprotection
- Release Of Cytochrome C From Mitochondria
PTMs
- Cleavage
- Phosphorylation
- Dephosphorylation
- Reduction
- Oxidation
- Acetylation
- Ubiquitination
- Methylation
- Nitrosylation
- Biotinylation
Research Areas
- Alzheimers Research
- Apoptosis
- Cancer
- Caspases
- Cell Biology
- Lipid and Metabolism
- Neurodegeneration
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP3
bosterbio.com/bosterbio-gene-info-cards/CASP3
References
PMID: 7983002 by Fernandes-Alnemri T., et al. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
PMID: 7774019 by Tewari M., et al. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
178 Publications of Boster Caspase-3 Antibodies & ELISA Kits
- PubMed ID: PMID:31933975, MicroRNA-124 represents a novel diagnostic marker in human lupus nephritis and p...
- PubMed ID: PMID:28559975, Inhibition of glioblastoma growth and invasion by 125I brachytherapy in rat glio...
- PubMed ID: PMID:26064215, Effects of PDTC on NF-κB expression and apoptosis in rats with severe acute pan...
- PubMed ID: 10.4103/1673-5374.153698, Ulinastatin suppresses endoplasmic reticulum stress and apoptosis in the hippoca...
- PubMed ID: 10.3969/j.issn.1673-5374.2013.23.009, Antenatal taurine reduces cerebral cell apoptosis in fetal rats with intrauterin...
- PubMed ID: 10.3892/mmr.2017.6160, Inhibitory effects of vitamin E on osteocyte apoptosis and DNA oxidative damage ...
- PubMed ID: 10.3389/fphar.2019.00988, Erxian Decoction Attenuates TNF-α Induced Osteoblast Apoptosis by Modulating th...
- PubMed ID: 10.3389/fmed.2021.732039, Hyperoxia Provokes Time- and Dose-Dependent Gut Injury and Endotoxemia and Alter...
- PubMed ID: 10.3389/fcvm.2021.659643, Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Thr...
- PubMed ID: 10.2147/DDDT.S265198, Integrated Network Pharmacology Analysis and Experimental Validation to Reveal t...
- PubMed ID: 10.1155/2020/3481758, Hydroxy-α-sanshool Possesses Protective Potentials on H2O2-Stimulated PC12 Cell...
- PubMed ID: 10.1142/S0192415X15500299, Apocynum venetum Attenuates Acetaminophen-Induced Liver Injury in Mice
- PubMed ID: 10.1111/os.13019, The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondra...
- PubMed ID: 10.1039/C7RA13726E, Shunaoxin dropping pill, a Chinese herb compound preparation, attenuates memory ...
- PubMed ID: 10.1038/srep30146, Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart dama...
- PubMed ID: 10.1016/j.wneu.2018.07.265, Adrenomedullin Reduces Secondary Injury and Improves Outcome in Rats with Fluid ...
- PubMed ID: 10.1016/j.toxicon.2007.07.020, Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus o...
- PubMed ID: 10.1016/j.taap.2016.05.009, Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidati...
- PubMed ID: 10.1016/j.physbeh.2015.07.036, The effects of acupuncture and traditional Chinese medicines on apoptosis of bra...
- PubMed ID: 10.1016/j.joen.2020.03.010, Effects of Calcitonin Gene-related Peptide on Dental Pulp Stem Cell Viability, P...
- PubMed ID: 10.1016/j.jep.2008.10.042, Total saponins of Panax Notoginseng modulate the expression of caspases and atte...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page