Research Spotlight – January 2019

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Untitled Document
Scientists of this month’s selected research publications investigate various aspects of several pathways such as the MAPK, Wnt/β-catenin, TGF-β1/Smad3, NF-κB, Akt/mTOR, and AMPK/ULK1 pathways.
BosterBio | Antibodies, ELISA kits, Detection Kits
Research Spotlight – January 2019

The January edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.

Scientists of this month’s selected research publications investigate various aspects of several pathways such as the MAPK, Wnt/β-catenin, TGF-β1/Smad3, NF-κB, Akt/mTOR, and AMPK/ULK1 signaling pathways.

Scroll down to learn more about these new scientific discoveries.

Luteolin inhibits IL-1β-induced inflammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model
Authors : Fei, J., Liang, B., Jiang, C., Ni, H., & Wang, L.
Journal : Biomedicine & Pharmacotherapy
Osteoarthritis (OA) is a joint disease characterized by inflammation and cartilage degradation. Accumulating evidence has demonstrated that luteolin, a natural flavonoid, has anti-inflammatory and anticatabolic effects. The present study…

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MicroRNA-30e inhibits adhesion, migration, invasion and cell cycle progression of prostate cancer cells via inhibition of the activation of the MAPK signaling pathway by downregulating CHRM3
Authors : Zheng, X.M., Zhang, P., Liu, M.H., Chen, P., & Zhang, W.B.
Journal : International Journal of Oncology
Prostate cancer (PCa) testing is currently based on measurement of serum prostate‑specific antigen levels and digital rectal examination, which are limited by a low predictive value and the adverse effects associated with overdiagnosis and…

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Effects of sprint interval or combined aerobic and resistance training on myokines in overweight women with type 2 diabetes: A randomized controlled trial
Authors : Banitalebi, E., Kazemi, A., Faramarzi, M., Nasiri, S., Haghighi, M.M.
Journal : Life Sciences
Our primary aim was to assess the effects of two different training modalities: sprint interval training (SIT) or combined aerobic and resistance training (A + R) on circulating myokines related to metabolic profile and adiposity in type 2 diabetes (T2D). Fifty…

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Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
Authors : Fiore, A., Ugel, S., De Sanctis, F., Sandri, S., Fracasso, G., Trovato,...
Journal : Nature Communications
Immunosuppression is a hallmark of tumor progression, and treatments that inhibit or deplete monocytic myeloid-derived suppressive cells could promote anti-tumor immunity. c-FLIP is a central regulator of caspase-8-mediated apoptosis and...

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Wnt/β-catenin signaling pathway contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury and is possibly related to the transforming growth factorβ1/Smad3 signaling pathway
Authors : Zhang, G., Ge, M., Han, Z., Wang, S., Yin, J., Peng, L., Xu, F., Zhang,...
Journal : Biomedicine & Pharmacotherapy
Aim: The Wnt/β-catenin signaling pathway plays an important role in ischemia-reperfusion(I/R) injury, and the transforming growth factor(TGF)-β/Smad signaling pathway participates in the neuroprotection effect induced by isoflurane(ISO) postconditioning...

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Cited Boster Product(s) : RIPA Lysis Buffer (AR0105)
TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling
Authors : Hou, Z., Guo, K., Sun, X., Hu, F., Chen, Q., Luo, X., Wang, G., Hu, J...
Journal : Molecular Cancer
Background: Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB2 has been reported to participate in regulating…

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Cited Boster Product(s) : Anti-GAPDH Picoband™ Antibody (A00227)
Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender
Authors : Porcu, C., Sideri, S., Martini, M., Cocomazzi, A., Galli, A., Tarantino...
Journal : International Journal of Molecular Sciences
Oleuropein (Ole) is one of the most plentiful phenolic compounds with antioxidant, anti-inflammatory, anti-atherogenic, hypoglycemic and hypolipidemic effects. The aim of our study was to establish whether the positive Ole-related effects on liver steatosis could...

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Hesperetin suppresses RANKL‐induced osteoclastogenesis and ameliorates lipopolysaccharide‐induced bone loss
Authors : Liu, H., Dong, Y., Gao, Y., Zhao, L., Cai, C., Qi, D., Zhu, M., Zhao, L...
Journal : Journal of Cellular Physiology
Destructive bone diseases caused by osteolysis are increasing in incidence. They are characterized by an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation of nuclear factor‐κB (NF‐κB) and mitogen‐activated protein…

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Differential effects of type 1 diabetes mellitus and subsequent osteoblastic β-catenin activation on trabecular and cortical bone in a mouse model
Authors : Chen, S., Liu, D., He, S., Yang, L., Bao, Q., Qin, H., Liu, H., Zhao, Y...
Journal : Experimental & Molecular Medicine
Type 1 diabetes mellitus (T1DM) is a pathological condition associated with osteopenia. WNT/β-catenin signaling is implicated in this process. Trabecular and cortical bone respond differently to WNT/β-catenin signaling in healthy mice. We…

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lncRNA-Six1 Is a Target of miR-1611 That Functions as a ceRNA to Regulate Six1 Protein Expression and Fiber Type Switching in Chicken Myogenesis
Authors : Ma, M., Cai, B., Jiang, L., Abdalla, B.A., Li, Z., Nie, Q., & Zhang, X.
Journal : Cells
Emerging studies indicate important roles for non-coding RNAs (ncRNAs) as essential regulators in myogenesis, but relatively less is known about their function. In our previous study, we found that lncRNA-Six1 can regulate Six1 in cis to participate in...

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