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Boster Bio Life Science Blog
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Today is World Cancer Day. Each year, organizations and people from around the world unite on February 4th to raise awareness about cancer.
According to the American Cancer Society, cancer mortality had dropped 32% from 1991 to 2019. This decline is mostly attributed to decreases in smoking and advancements in early cancer detection and treatment.
Despite this reduction in cancer mortality, cancer remains as a major public health problem worldwide. Globally, 1 out of 6 deaths...
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We’re excited to present our first Research Spotlight edition of 2022, which features the latest scientific innovations from researchers whom Boster has served.
In this issue, scientists explore the signaling mechanisms of GDF11 during aging, TAF7 during gene expression, OTUD1 in intestinal inflammatory diseases, and the m6Am mRNA in the regulation of obesity.
January 2022We’re excited to present our first Research Spotlight edition of 2022, which features the latest scientific innovations from researchers whom Boster has served.
In this issue, scientists explore the signaling mechanisms of GDF11 during aging, TAF7 during gene expression, OTUD1 in intestinal inflammatory diseases, and the m6Am mRNA in the regulation of obesity.
We have also highlighted several studies discussing novel strategies in nanomedicine to help advance modern healthcare, inc...
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As of January 2022, there are nearly 2,500 brain-derived neurotrophic factor (BDNF) antibodies to choose from according to CiteAb. In this article, I will share how I found the BDNF antibody that worked for my projects and I hope my experience is helpful if you are currently searching for good BDNF antibodies. I will also discuss the expected BDNF molecular weight in Western blots, BDNF positive and negative control designs, and a step-by-step guide of how I currently search for antibodies.
During my first year in the lab, my team was investigating BDNF’s role in Rett syndrome by treating various CNS cells with inflammatory cytokines in vitro and we discovered upregulation of BDNF mRNAs. Since we had to conduct protein level analysis, I started the hunt for anti-BDNF antibodies.
Almost any scientist who has worked with antibodies knows that many unexpected issues can occur even for the most well-known biomarkers and established antibodies. To prepare for the antibody search, I generally get 2 facts sorted out first:
- The expected molecular weight the biomarker has in Western blotting
- The tissues/cells known to express or not express the b ...
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In our last edition of Research Spotlight this year, we're happy to feature 10 recent publications from scientists whom Boster has served.
Among the studies, scientists investigate the mechanisms of m6a reader for colorectal cancer, the anti-metastatic roles of dsRNA mimics, and the effects of USP12 on breast cancer angiogenesis.
In addition, scientists explore Vitamin D3's antioxidative stress ability as well as the lungfish cocoon's antimicrobial functions. Researchers also develop pitavastatin-loaded multilayer films that enhance osseointegration of metal implants.
Scroll down to find out more about these discoveries!
...Vitamin D3 Protects Mice from Diquat-Induced Oxidative Stress through the NF-κB/Nrf2/HO-1 Signaling Pathway
Authors: Zhang, H., Liu, Y., Fang, X., Gu, L., Luo, C., Chen, L., Wang, Q.
Journal: Oxidative Medicine and Cellular LongevityVitamin D3, as an indispensable and fat-soluble micronutrient, plays an important role in the health of humans and animals. At
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Our November edition of Research Spotlight highlights 10 research studies that provide deeper insights on the biological functions of several key biomarkers and their clinical translational potential.
Two studies reveal new insights for diabetes treatment by investigating the functions of PGRMC1 and an m6A reader protein for insulin metabolism and delayed diabetic wound healing respectively.
Scientists also perform bioinformatics and immunological analysis of several regulatory...
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We're delighted to bring you our October edition of Research Spotlight, featuring 10 new publications of various fields from scientists whom Boster has served.
This month, research papers delve into nanotechnology advancements using polydopamine nanoparticles, PLGA nanoparticles, and HA-coated collagen nanofibers for cancer treatments and regenerative medicine.
Scientists also investigate how exercise can ameliorate tumor-associated anemia, how the SARS-CoV-2...
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The September edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.
This month’s selected research papers characterize the underlying mechanisms of several cancers, HIV, and other systemic diseases. Among the studies, monoclonal antibodies and a tumor nanovaccine are explored as therapeutic treatments for different cancers.
Scientists also demonstrate how a 3D-printed biphasic scaffold can enhance cartilage regeneration. In addition, the role of PEDF in collagen synthesis and its implications for tissue expansion in plastic surgery is investigated.
Keep scrolling to find out more about these research studies.
Characterizing Dedifferentiation of Thyroid Cancer by Integrated Analysis
Authors: Luo, H., Xia, X., Kim, G.D., Liu, Y., Xue, Z., Zhang, L., Shu, Y., Yang, T...
Journal: Science AdvancesUnderstanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and...
Cited Boster Product(s): Anti-Vimentin Antibody Picoband™ (PB9359); Anti-E Cadherin 1/CDH1 Antibody Picoband™ (PB9561)
Oral Immune Dysfunction is Associated with the Expansion of FOXP3+PD-1+Amphiregulin+ T Cells During HIV Infection
Authors: Bhaskaran, N., Schneider, E., Faddoul, F., da Silva, A.P., Asaad, R...
Journal: Nature Communications>Residual systemic inflammation and mucosal immune dysfunction persist in people living with HIV, despite treatment with combined anti-retroviral therapy, but the underlying immune mechanisms are poorly understood. Here we report that the altered immune landscape of the oral mucosa of HIV-positive patients on therapy involves...
Cited Boster Product(s): Human CD14 ELISA Kit PicoKine™ (EK0694); Human TLR2/Toll-Like Receptor 2 ELISA Kit PicoKine™ (EK0906); Human Cotinine ELISA Kit (Competitive EIA) (EK7035); Human Amphiregulin(AR) / AREG ELISA Kit PicoKine™ (EK0304); Human IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0392); Human IL-6/Interleukin-6 ELISA Kit PicoKine™ (EK0410)
Increased Plasmin-Mediated Proteolysis of L1CAM in a Mouse Model of idiopathic Normal Pressure Hydrocephalus
Authors: Yang, D., Yang, H., Luiselli, G., Ogagan, C., Dai, H., Chiu, L...
Journal: PNAS (Proceedings of the National Academy of Sciences of the United States of America)Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder that is characterized by enlarged cerebral ventricles, gait difficulty, incontinence, and dementia. iNPH usually develops after the sixth decade of life in previously asymptomatic individuals. We recently reported that loss-of-function deletions in CWH43...
Cited Boster Product(s): Anti-Plasminogen Antibody Picoband™ (A03674-1)
Cooperating Minimalist Nanovaccine with PD-1 Blockade for Effective and Feasible Cancer Immunotherapy
Authors: Jiang, M., Zhao, L., Cui, X., Wu, X., Zhang, Y., Guan, X., Ma, J...
Journal: Journal of Advanced ResearchIntroduction: Tumor vaccine has been a research boom for cancer immunotherapy, while its therapeutic outcome is severely depressed by the vulnerable in vivo delivery efficiency. Moreover, tumor immune escape is also another intractable issue, which has badly whittled down the therapeutic efficiency. Objectives: Our study aims to solve...
Cited Boster Product(s): FITC Conjugated Avidin (BA1125)
...Blockade of CHRNB2 Signaling with a Therapeutic Monoclonal Antibody Attenuates the Aggressiveness of Gastric Cancer Cells
Authors: Kanda, M., Shimizu, D., Nakamura, S., Sawaki, K., Umeda, S...
Journal: OncogeneHere, we evaluated the therapeutic potential of antibodies (Abs) targeting cholinergic receptor nicotinic beta 2 subunit (CHRNB2) in gastric cancer. To investigate
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Our August edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.
In this month’s edition, research studies delve into the behavioral and cognitive parts of the brain and investigate how various cytokine levels are associated with the progression of neurodegenerative disorders. A comprehensive evaluation of the efficacy and safety of using stem cell therapy for traumatic brain injury is also discussed.
Researchers explore additional...
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In the July edition of Research Spotlight, we hand-picked a range of scientific publications that investigate several new approaches to control the development of chronic and morbid diseases without systemic side effects.
Among the studies, researchers discuss how modulations of IL-1β-primed ERCs, IL-23, Lnc-408, and LncRNA CERS6-AS1 levels could alleviate the pathological damages of ulcerative colitis, breast cancer, and pancreatic cancer respectively. Associations between prenatal acrylamide exposure with decreased fetal growth are also further explored.
Scroll down to learn about new drug delivery platforms and therapies, and discover more about the immune response towards diseases.
IL-1β Pre-Stimulation Enhances the Therapeutic Effects of Endometrial Regenerative Cells on Experimental Colitis
Authors: Yu, D., Zhao, Y., Wang, H., Kong, D., Jin, W., Hu, Y., Qin, Y…
Journal: Stem Cell Research & TherapyBackground: Ulcerative colitis (UC) is a chronic, relapsing, and non-specific inflammatory bowel disease, and the current treatment strategies were mainly used to relieve symptoms or for maintenance. Endometrial regenerative cells (ERCs) are mesenchymal-like stromal cells and have been demonstrated to alleviate multiple immune...
Cited Boster Product(s): Anti-Mannose Receptor/MRC1 Picoband™ Antibody (A02285-2); Mouse IFN Gamma ELISA Kit PicoKine™ (EK0375); Mouse IL-17 ELISA Kit PicoKine™ (EK0431); Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-6 ELISA Kit PicoKine™ (EK0411); Mouse IL-4 ELISA Kit PicoKine™ (EK0405); Mouse IL-10 ELISA Kit PicoKine™ (EK0417)
...Intravenous Delivery of Lung-Targeted Nanofibers for Pulmonary Hypertension in Mice
Authors: Marulanda, K., Mercel, A., Gillis, D.C., Sun, K., Gambarian, M…
Journal: Advanced Healthcare MaterialsPulmonary hypertension is a highly morbid disease with no cure. Available treatments are limited by systemic adverse effects
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Our June edition of Research Spotlight presents 10 recent research papers from scientists whom Boster has served.
In the selected studies, you will learn how the research community is developing more efficient ways for drug delivery, utilizing biomaterials in therapeutic treatments, exploring various pathological reactions, and many more.
Among the papers, scientists investigate how the apoptotic process can be used to load drugs for brain-targeted delivery with much higher efficiency than other extracellular vesicles. The role and antioxidant effects of spinach methanolic extract in the prevention of retinal degeneration is also demonstrated.
Scroll down to discover more about each new research publication.
Delivering Antisense Oligonucleotides across the Blood-Brain Barrier by Tumor Cell-Derived Small Apoptotic Bodies
Authors: Wang, Y., Pang, J., Wang, Q., Yan, L., Wang, L., Xing, Z, Wang, C…
Journal: Advanced ScienceThe blood-brain barrier (BBB) is the most restrictive and complicated barrier that keeps most biomolecules and drugs from the brain. An efficient brain delivery strategy is urgently needed for the treatment of brain diseases. Based on the studies of brain-targeting extracellular vesicles (EVs), the potential of using small apoptotic...
Cited Boster Product(s): Anti-ZO1 Tight Junction Protein/TJP1 Antibody Picoband™ (PB9234); Anti-RAB11B Antibody Picoband™ (A04526-1)
Calcium Phosphate-Based Materials Regulate Osteoclast-Mediated Osseointegration
Authors: Wang, X., Yu, Y., Ji, L., Geng, Z., Wang, J., Liu, C.
Journal: Bioactive MaterialsCalcium phosphate-based materials (CaP) have been widely used as bone graft substitutes with a decent osseointegration. However, the mechanism whereby cells function and repair the bone defect in CaP micro-environment is still elusive. The aim of this study is to find the mechanism how osteoclast behaviors mediate bone healing with...
Cited Boster Product(s): Mouse RANK / CD265 ELISA Kit PicoKine™ (EK0830)
Calcium Silicate-Human Serum Albumin Composite Hydrogel Decreases Random Pattern Skin Flap Necrosis by Attenuating Vascular Endothelial Cell Apoptosis and Inflammation
Authors: Xu, P., Xing, M., Huang, H., Xue, K., Chang, J., Liu, K.
Journal: Chemical Engineering JournalRandom pattern skin flaps are commonly used in plastic surgery to repair skin defects. However, as flap survival mainly relies on blood supply from the distal pedicle and the wound bed, the distal part of the flap is prone to necrosis. Subsequent pathological reactions, including inflammatory reactions, cell apoptosis, and oxidative...
Cited Boster Product(s): DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining (AR1176)
Development of Novel Nanofibers Targeted to Smoke-Injured Lungs
Authors: Mercel, A.I., Marulanda, K., Gillis, D.C., Sun, K., Clemons, T.D…
Journal: BiomaterialsSmoke inhalation injury is associated with significant mortality and current therapies remain supportive. The purpose of our study was to identify proteins upregulated in the lung after smoke inhalation injury and develop peptide amphiphile nanofibers that target these proteins. We hypothesize that nanofibers targeted to angiotensin...
Cited Boster Product(s): Anti-Angiotensin Converting Enzyme 1/ACE Antibody Picoband™ (PB9124)
TRAIL-Armed ER Nanosomes Induce Drastically Enhanced Apoptosis in Resistant Tumor in Combination with the Antagonist of IAPs (AZD5582)
Authors: Hou, H., Su, K., Huang, C., Yuan, Q., Li, S., Sun, J., Lin, Y, Du, Z...
Journal: Advanced Healthcare MaterialsAlthough mesenchymal stem cells (MSCs) can be engineered to deliver the TNF-related apoptosis-inducing ligand (TRAIL) as an effective anticancer therapy, the clinical application is hampered by the costly manufacturing of therapeutic MSCs. Therefore, it is needed to find an alternative cell-free therapy. In this study, TRAIL-armed...
Cited Boster Product(s): 5nm Colloidal Gold Labeled Secondary Antibody, Goat Anti-Rabbit IgG (H+L) (GA1013)
Bufalin Targets the SRC-3/MIF Pathway in Chemoresistant Cells to Regulate M2 Macrophage Polarization in Colorectal Cancer
Authors: Chen, J., Wang, H., Jia, L., He, J., Li, Y., Liu, H., Wu, R., Qiu, Y...
Journal: Cancer Letters>M2-polarized macrophages are one of critical factors in tumour chemoresistance. An increasing number of studies have shown that M2 macrophage polarization can be promoted by chemoresistance. A large number of evidences indicate that Bufalin has significant antitumour effect, previous studies have found that Bufalin can reduce the...
Cited Boster Product(s): Human IL-10/Interleukin-10 ELISA Kit PicoKine™ (EK0416); Human TGF Beta 1 ELISA Kit PicoKine™ (EK0513); Mouse IL-10/Interleukin-10 ELISA Kit PicoKine™ (EK0417); Mouse TGF Beta 1 ELISA Kit PicoKine™ (EK0515)
Metalloproteinase 1 Downregulation in Neurofibromatosis 1: Therapeutic Potential of Antimalarial Hydroxychloroquine and Chloroquine
Authors: Tsuji, G., Yumine, A.T., Kato, T., Furue, M.
Journal: Cell Death & DiseaseNeurofibromatosis type 1 is an autosomal dominant genetic disorder caused by mutation in the neurofibromin 1 (NF1) gene. Its hallmarks are cutaneous findings including neurofibromas, benign peripheral nerve sheath tumors. We analyzed the collagen and matrix metalloproteinase 1 (MMP1) expression in Neurofibromatosis 1 cutaneous...
Cited Boster Product(s): Human MMP-1 ELISA Kit PicoKine™ (EK0458)
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3
Authors: Zhang, C., Suo, M., Liu, L., Qi, Y., Zhang, C., Xie, L., Zheng, X...
Journal: Oxidative Medicine and Cellular LongevityOxidative stress and apoptosis play a vital role in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The purpose of our study was to investigate the protective effects and mechanisms of melatonin against CI-AKI in a CI-AKI mouse model and NRK-52E cells. We established the CI-AKI model in mice, and the animals were...
Cited Boster Product(s): Anti-Lipocalin 2/LCN2 Antibody Picoband™ (PB9609)
Spinach Methanolic Extract Attenuates the Retinal Degeneration in Diabetic Rats
Authors: Pérez, R.B., Martinez, A.C., Velázquez, E.G., Rosas, M.M...
Journal: AntioxidantsIt has been suggested that spinach methanolic extract (SME) inhibits the formation of advanced glycation end products (AGEs), which are increased during diabetes progression, so it is important to know if SME has beneficial effects in the diabetic retina. In this study, in vitro assays showed that SME inhibits glycation, carbonyl...
Cited Boster Product(s): Anti-Nitric Oxide Synthase (Inducible) Nos2 Antibody (A00368-1)
Proteomics and Transcriptomics Jointly identify the Key Role of Oxidative Phosphorylation in Fluoride-Induced Myocardial Mitochondrial Dysfunction in Rats
Authors: Xie, J., Zhao, Y., Dong, N., Tian, X., Feng, J., Liu, P., Li, M...
Journal: Ecotoxicology and Environmental SafetyThe regulation of mitochondrial function, which is dominated by oxidative phosphorylation (OXPHOs), is important in fluoride induced cardiovascular disease. Based on the previous study of fluoride-induced mitochondrial structure and membrane potential abnormalities, this study integrated ITRAQ protein quantification and RNA-Seq...
Cited Boster Product(s): HRP Conjugated Goat Anti-Rabbit IgG SABC Kit (SA1022);
Our June edition of Research Spotlight presents 10 recent research papers from scientists whom Boster has served.
In the selected studies, you will learn how the research community is developing more efficient ways for drug delivery, utilizing biomaterials in therapeutic treatments, exploring various pathological reactions, and many more.
Among the papers, scientists investigate how the apoptotic process can be used to load drugs for brain-targeted delivery with much higher efficiency...
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