Many biological assays use antibodies to detect PROC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PROC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PROC antibodies...
We validate the specificity of these antibodies to PROC by testing them on tissues known to express PROC positively and negatively. Browse below to find the PROC antibody that suites your experiment. We have 100 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Designing a Western blot for PROC?
The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
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Gene Information
Human
Gene Name:
PROC
Uniprot:
P04070
Entrez:
5624
Family
Belongs to:
peptidase S1 family
Alternative Names
Anticoagulant protein C; APC; Autoprothrombin IIA; Blood coagulation factor XIV; Coagulation Factor XIV; EC 3.4.21; EC 3.4.21.69; PC; PROC; PROC1; protein C (inactivator of coagulation factors Va and VIIIa); Protein C; vitamin K-dependent protein C
Molecular Weight
Mass (kDA): 52.071 kDA
Genomic Context
Human
Location:
2q14.3
Sequence:
2; NC_000002.12 (127418143..127429246)
Tissue Specificity
Plasma; synthesized in the liver.
Subcellular Localizations
Secreted. Golgi apparatus. Endoplasmic reticulum.
Diseases
Salmonella Infections
Tuberculosis
Liver Diseases
Infective Disorder
Pain
Malignant Neoplasms
Neoplasms
Fracture
Congenital Heart Defects
Syphilis
Liver Dysfunction
Atherosclerosis
Staphylococcal Infections
Abscess
Chromosome Inversion
Cancer Patients And Suicide And Depression
Heart Diseases
Depressive Disorder
Stenosis
Cerebrovascular Accident
Interacting Proteins
MMP15
Pathways
Transport
Translation
Virulence
Mating
Secretion
Transposition
Urea Cycle
Fermentation
Coagulation
Pathogenesis
Cell Activation
Fertilization
Aging
Hypersensitivity
Sporulation
Reflex
Oligopeptide Transport
Antiport
Nitrogen Fixation
Cell Cycle
PTMs
Phosphorylation
Nitration
Oxidation
Reduction
Carbamylation
Glycosylation
Dephosphorylation
Research Areas
Apoptosis
Cancer
For details, visit: bosterbio.com/bosterbio-gene-info-cards/PROC
References
PMID: 2991859 by Beckmann R.J., et al. The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs.
PMID: 2991887 by Foster D.C., et al. The nucleotide sequence of the gene for human protein C.
577 Publications of Boster PROC Antibodies & ELISA Kits
PubMed ID: 38819709, Wang Meng, Zhong Liang, Zhang Hongyan, Wan Peng, Chu Xuan, Shao Xin, Chen Shuyu,...
PubMed ID: 10.7150/thno.41028, TMEM16A ameliorates vascular remodeling by suppressing autophagy via inhibiting ...
PubMed ID: 10.4049/jimmunol.1602175, The Upregulation of Integrin αDβ2 (CD11d/CD18) on Inflammatory Macrophages Pro...
PubMed ID: 10.3892/ol.2021.13091, Integrated bioinformatics analyses of key genes involved in hepatocellular carci...
PubMed ID: 10.3892/mmr.2019.10175, Effect of endoplasmic reticulum stress involved in manganese‑induced neurotoxi...
PubMed ID: 10.3892/ijmm.2019.4255, CaSR activates PKCδ to induce cardiomyocyte apoptosis via ER stress‑associate...
PubMed ID: 10.3390/ijms20040920, Potential Analysis and Preparation of Chitosan Oligosaccharides as Oral Nutritio...
PubMed ID: 10.3390/antiox10020176, Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-...
PubMed ID: 10.3389/fphar.2019.00307, Activation of CXCL6/CXCR1/2 Axis Promotes the Growth and Metastasis of Osteosarc...
PubMed ID: 10.1186/s12935-020-01297-6, GSK-J4 induces cell cycle arrest and apoptosis via ER stress and the synergism b...
PubMed ID: 10.1177/2472555216685519, Identification and Validation of Gene Expression Patterns in Cystitis Glandulari...
PubMed ID: 10.1177/20587392211058615, Curcumin suppresses neuroinflammation to protect neurons by preventing NLRP3 inf...
PubMed ID: 10.1155/2018/4310419, Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and...
PubMed ID: 10.1152/ajprenal.00428.2016, IL-6 promotes epithelial-to-mesenchymal transition of human peritoneal mesotheli...