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Doesn't require ATP. Maintains partially unfolded proteins in a country suitable for subsequent refolding by other chaperones, for example HSPA8/HSC70.
|Sequence:||8; NC_000008.11 (27596917..27614700, complement)|
Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.
[Isoform 1]: Secreted. Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.; [Isoform 4]: Cytoplasm. Keeps cytoplasmic localization in stressed and unstressed cell.; [Isoform 6]: Cytoplasm. Keeps cytoplasmic localization in stressed and unstressed cell.; Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Mitochondrion. Mitochondrion membrane. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Secreted isoforms can retrotransl
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