Clusterin (CLU)

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Inhibits formation of amyloid fibrils from APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro).

Doesn't require ATP. Maintains partially unfolded proteins in a country suitable for subsequent refolding by other chaperones, for example HSPA8/HSC70.