Angiotensin-converting enzyme (ACE)

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator.

Has also a glycosidase activity that releases GPI-anchored proteins from the membrane by cleaving the mannose linkage from the GPI moiety. .