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- Table of Contents
10 Citations 8 Q&As
1 Citations 16 Q&As
2 Citations 15 Q&As
4 Citations 5 Q&As
2 Citations 15 Q&As
1 Citations 3 Q&As
Facts about Angiotensin-converting enzyme.
Has also a glycosidase activity that releases GPI-anchored proteins from the membrane by cleaving the mannose linkage from the GPI moiety. .
Human | |
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Gene Name: | ACE |
Uniprot: | P12821 |
Entrez: | 1636 |
Belongs to: |
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peptidase M2 family |
ACE; ACE1angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; carboxycathepsin; CD143 antigen; CD143; DCP; DCP1; DCP1angiotensin-converting enzyme; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase I; EC 3.2.1.-; EC 3.4.15.1; Kininase II; MGC26566; MVCD3; peptidase P; testicular ECA
Mass (kDA):
149.715 kDA
Human | |
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Location: | 17q23.3 |
Sequence: | 17; NC_000017.11 (63477061..63498373) |
Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.
[Angiotensin-converting enzyme, soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm. Detected in both cell membrane and cytoplasm in neurons.
If you've been researching the ACE Marker, you've probably been a bit confused. What is it exactly? These questions and more will be answered in this article. Learn how the ACE marker reacts to ACE as well as the anti-ACE2 antibody, and the advantages of using it. We'll also look at some typical issues that this marker may help you with. Read on to find out what makes the ACE Marker so useful, and how you can use it to accomplish your goals.
There are numerous biological tests that can detect ACE. They include ELISA, IF and IHC. A majority of these tests employ antibodies specifically designed for the purpose of detecting the ACE marker. Boster Bio uses rabbit and mouse samples to develop its antibodies. Antibodies recognize the ACE mark by binding to its amino acid sequence. The sequence is centered around amino acids 180 - 230. These antibodies are highly specific for ACE which makes them extremely useful in studies of immunology.
The anti-ACE2 antibody made by Boster Bio is a globally recognized monoclonal antibody with high-quality and high-quality. It has been tested in ELISA, in immunofluorescence (IF) and immunohistochemistry (IHC), and Western blotting. The amino acids that the antibody targets 180-230 are identical to the human ACE2. You can purchase a blocking peptide that will lengthen the immunogen and reduce the cost.
Presently, a variety of protein subunit candidates are currently in human clinical trials. These vaccine candidates are designed to produce neutralizing antibodies that recognize spike proteins on the virus particles. This will block viral entry from human cells by blocking the receptor ACE2. These vaccines are developed on different platforms each with its own strengths and weaknesses. We will discuss the similarities and differences between each platform.
Genetic variation in the ACE gene is believed to be associated with various diseases. Recent studies in West African countries revealed an inverse correlation between ACE allele frequency, and severity of the disease. It is interesting to note that the ACE gene is also connected to historical migrations of human populations. For example, the frequency of the 7*37% II genotype within the Lebanese population is 7*37%. Therefore, the ACE gene may provide important data on the human history of migration and the pharmacological significance of this enzyme in various populations.
The ACE enzyme is responsible for cleaving sub-substances of peptides with an amino group that is acylated to the terminal. The simplest cleaved protein is Z-Phe His-Leu tripeptide. Angiotensin II is the penultimate proline residue. It is also able tolerate modifications at the antepenultimate location on the peptide substrate.
This enzyme inhibitor is effective for moderate to mild hypertension and cardiovascular diseases. ACE inhibitors also work in preventing myocardial injuries and collagen vascular disease. The availability of these medications has a significant effect on the effectiveness of ACE inhibitors. Therefore the availability of effective and safe drugs is crucial for the treatment of cardiovascular diseases. This enzyme inhibitor is a great option for this purpose.
This metabolic enzyme can be monitored shortly after the diet is introduced. Dieters who have been following a diet for at least 24 hours can determine the amount of ACE in their urine. These measurements can be a valuable indicator of their diet and progress. The urine levels could be related to BMI or weight loss. The ACE marker could be an early biofeedback marker that could be connected with the efficacy of diet and weight loss.
You've come to the right place for those looking for an affordable and reliable marker. ACE offers a wide array of products that are perfect for a variety of applications, including signage and branding. The company is dedicated to in collaborating with customers to increase their product selection and streamline their processes. For a variety of uses, ACE offers a custom-designed marker that suits your needs and fits your budget.
ACE has been associated with weight loss. This makes it an important biomarker. Because ACE levels can be measured at any time, even 24 hours after beginning on a diet and this blood test can provide information to people about their progress. ACE levels in the urine may also be related to weight loss and BMI. The benefits of using ACE markers are numerous. These markers are an easy affordable way to track your progress or provide feedback to dieters.
An additional advantage to using an ACE Marker to treat hypertension is that it can be utilized in different areas too. It is commonly used to treat secondary hypertension. It also helps improve the control of blood pressure, it aids physicians to discover the compensatory mechanisms ACE inhibitors. The ACE-S test is a way to optimize ACEi dosages for first-line patients. Its use in hypertension that is secondary could be a boon to healthcare professionals who wish to maximize the effectiveness of these medications.
PMID: 2849100 by Soubrier F., et al. Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
PMID: 2547653 by Lattion A.L., et al. The testicular transcript of the angiotensin I-converting enzyme encodes for the ancestral, non-duplicated form of the enzyme.
*More publications can be found for each product on its corresponding product page