Many biological assays use antibodies to detect Angiogenin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Angiogenin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Angiogenin antibodies...
We validate the specificity of these antibodies to Angiogenin by testing them on tissues known to express ANG positively and negatively. Browse below to find the ANG antibody that suites your experiment. We have 98 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA.
Cleaves tRNA within anticodon loops to generate tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues.
Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
Subcellular Localizations
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus. Nucleus, nucleolus. Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708).
Diseases
Hypertensive Disease
Hypertrophy
Pathologic Vasoconstriction
Fibrosis
Kidney Diseases
Heart Failure
Inflammation
Cardiovascular Diseases
Cardiac Hypertrophy
Diabetes Mellitus
Atherosclerosis
Disease Of Adrenal Medulla
Tumor Angiogenesis
Nervousness
Stenosis
Infarction
Myocardial Infarction
Proteinuria Of Undiagnosed Cause
Neoplasms
Pathologic Neovascularization
Interacting Proteins
ACTN2
ANXA2
FST
PCNA
PLAUR
RNH1
S100A10
Pathways
Secretion
Excretion
Vasoconstriction
Pathogenesis
Glomerular Filtration
Angiogenesis
Cell Proliferation
Localization
Cell Growth
Transport
Vasodilation
Reflex
Natriuresis
Aldosterone Secretion
Aging
Regulation Of Blood Pressure
Cell Death
Cell Cycle
Diuresis
Cell Migration
PTMs
Phosphorylation
Cleavage
Oxidation
Reduction
Dephosphorylation
Nitration
Glycosylation
Acetylation
Iodination
Myristoylation
Ribosylation
Hydroxylation
Ubiquitination
Methylation
Phosphorothioation
Decarboxylation
Carboxylation
Geranylgeranylation
Deglycosylation
Prenylation
For details, visit: bosterbio.com/bosterbio-gene-info-cards/ANG
References
PMID: 2866795 by Kurachi K., et al. Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor.
PMID: 11919285 by Zhang J., et al. Diversifying selection of the tumor-growth promoter angiogenin in primate evolution.
79 Publications of Boster Angiogenin Antibodies & ELISA Kits
PubMed ID: PMID:30210698, Identification and differentiation therapy strategy of pterygium in vitro
PubMed ID: PMID:25973012, Biocompatibility of porcine small intestinal submucosa and rat endothelial proge...