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- Table of Contents
KIT Antibodies
AND KIT ELISA kits, KIT Proteins
Many biological assays use antibodies to detect KIT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KIT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KIT antibodies...
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KIT Infographic by Boster Bio
All KIT Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK0835
96 wells/kit, with removable strips.
Cat # EK0835
96 wells/kit, with removable strips.
Anti-c-Kit Antibody Picoband®
4 Citations 1 Q&As
Human
Flow Cytometry, IHC, ICC, WB
$370
Cat # PB9258
100 μg/vial
Cat # PB9258
100 μg/vial
Mouse
ELISA
$499
Cat # EK1581
96 wells/kit, with removable strips.
Cat # EK1581
96 wells/kit, with removable strips.
Human
IHC, WB
$449
Cat # M01335-2
100uL
Cat # M01335-2
100uL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2449
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2449
1 kit, containing two 96-well plates and all necessary reagents
Cow, Human, Primate
Flow Cytometry, IP, IHC-F, ICC
$299
Cat # M01335-3
0.1 mg
Cat # M01335-3
0.1 mg
Mouse
ELISA
$499
Cat # FEK1581
96 wells/kit, with removable strips.
Cat # FEK1581
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # FEK0835
96 wells/kit, with removable strips.
Cat # FEK0835
96 wells/kit, with removable strips.
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01335-6
100 μg
Cat # M01335-6
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01335-7
100 μg
Cat # M01335-7
100 μg
Cynomolgus monkey, Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01335-8
100 μg
Cat # M01335-8
100 μg
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P01335-1
100 μl/vial
Cat # P01335-1
100 μl/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P01335-2
100 μl/vial
Cat # P01335-2
100 μl/vial
KIT Overview
Facts about Mast/stem cell growth factor receptor Kit.
Mast/stem cell growth factor receptor Kit (KIT)
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell growth, migration and function, and in melanogenesis. In reaction to KITLG/SCF binding, KIT can activate several signaling pathways.
Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase.
Gene Information
| Human | |
|---|---|
| Gene Name: | KIT |
| Uniprot: | P10721 |
| Entrez: | 3815 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CD117 antigen; CD117; ckit; c-kit; EC 2.7.10; EC 2.7.10.1; KIT; PBT; piebald trait; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCF R; SCFR; SCFRmast/stem cell growth factor receptor; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Molecular Weight
Mass (kDA):
109.865 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q12 |
| Sequence: | 4; NC_000004.12 (54657928..54740715) |
Tissue Specificity
Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cytoplasm. Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
Diseases
- Neoplasms
- Malignant Neoplasms
- Gastrointestinal Stromal Tumors
- Carcinoma
- Leukemia
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Hepatitis
- Infective Disorder
- Inflammation
- Stromal Neoplasm
- Myeloid Leukemia
- Malignant Neoplasm Of Breast
Pathways
- Pathogenesis
- Cell Proliferation
- Secretion
- Cell Death
- Cell Growth
- Cell Cycle
- Localization
- Angiogenesis
- Reverse Transcription
- Immune Response
- Transport
- Excretion
- Drug Resistance
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Oxidation
- Glycosylation
- Biotinylation
- Nitration
- Reduction
- Acetylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KIT
bosterbio.com/bosterbio-gene-info-cards/KIT
References
PMID: 2448137 by Yarden Y., et al. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
PMID: 1279499 by Giebel L.B., et al. Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene.
24 Publications of Boster KIT Antibodies & ELISA Kits
- PubMed ID: 10.3892/or_00000761, Characterization of primary ovarian cancer cells in different culture systems
- PubMed ID: 10.3892/or.16.5.1021, Histological type of oncogenity and expression of cell cycle genes in tumor cell...
- PubMed ID: 10.3748/wjg.v13.i28.3886, Selective tropism of liver stem cells to hepatocellular carcinoma in vivo
- PubMed ID: 10.14309/ctg.0000000000000388, The Number of Interstitial Cells of Cajal Differs Among Different Subtypes of Ac...
- PubMed ID: 10.1159/000204750, Isolation, Culture and Characterization of Cardiac Progenitor Cells Derived from...
- PubMed ID: 10.1093/abbs/gmq067, Cancer stem-like cells can be isolated with drug selection in human ovarian canc...
- PubMed ID: 10.1016/j.jpedsurg.2009.07.061, The expression of Cajal cells at the obstruction site of congenital pelviureteri...
- PubMed ID: 28115023, Astaxanthin attenuates total body irradiation-induced hematopoietic system injur...
- PubMed ID: 23533594, Liu J, Wang Y, Du W, Liu W, Liu F, Zhang L, Zhang M, Hou M, Liu K, Zhang S, Yu B...
- PubMed ID: 25484117, Yang B, Zhou Xc, Lan C. Mol Med Rep. 2015 Apr;11(4):2735-40. Doi: 10.3892/Mmr.20...
- PubMed ID: 17582792, Ge C, Zhang C, Ye J, Tang X, Wu Y. Cell Biol Int. 2007 Oct;31(10):1251-6. Epub 2...
- PubMed ID: 22294837, Bin Wt, Ma Lm, Xu Q, Shi Xl. World J Gastroenterol. 2012 Jan 28;18(4):309-22. Do...
- PubMed ID: 24140441, Liu W, Peng Qx, Lin Xl, Luo Ch, Jiang Mj, Mo Zx, Yung Kk. Fitoterapia. 2014 Jan;...
- PubMed ID: 24939298, Zhang H, Li L, Xu Gy, Mei Yw, Zhang Jj, Murong Sx, Sun Sg, Tong Et. J Huazhong U...
- PubMed ID: 24746831, Tang Y, Li Y, Yu H, Gao C, Liu L, Chen S, Xing M, Liu L, Yao P. J Nutr Biochem. ...
- PubMed ID: 21486673, Bao Hj, Liu Y, Qin Jh, Xu Cs, Hei Nn, Jaber Jr, Chen Qs. Res Vet Sci. 2011 Dec;9...
- PubMed ID: 21956205, Lan F, Yue X, Han L, Shi Z, Yang Y, Pu P, Yao Z, Kang C. Int J Oncol. 2012 Feb;4...
- PubMed ID: 24836450, Ban Jb, Fan Xw, Huang Q, Li Bf, Chen C, Zhang Hc, Xu Sq. Plos One. 2014 May 16;9...
- PubMed ID: 21660447, Wang Tb, Wei Xq, Lin Wh, Shi Hp, Dong Wg. Clin Exp Med. 2012 Jun;12(2):89-95. Do...
- PubMed ID: 22544356, Chuangui C, Peng T, Zhentao Y. Pathol Oncol Res. 2012 Oct;18(4):1021-7. Epub 201...
- PubMed ID: 25805932, Xu Yf, Ge Fj, Han B, Yang Xq, Su H, Zhao Ac, Zhao Mh, Yang Yb, Yang J. World J G...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page